FC131

Cat. No.: HY-P1104: FAQs
Data Sheet Handling Instructions

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FC131 is a potent CXCR4 antagonist. FC131 inhibits [¹²⁵I]-SDF-1 binding to CXCR4 with an IC₅₀ of 4.5 nM. FC131 has anti-HIV activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

FC131 Chemical Structure

CAS No. : 606968-52-9

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Other Forms of FC131:

FC131 TFA Get quote

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

FC131 is a potent CXCR4 antagonist. FC131 inhibits [¹²⁵I]-SDF-1 binding to CXCR4 with an IC₅₀ of 4.5 nM. FC131 has anti-HIV activity^[1].

IC₅₀ & Target

¹²⁵I-SDF-CXCR4

4.5 nM (IC₅₀)

HIV

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	> 30 μM Compound: 1a	Inhibition of [125I]SDF-1alpha binding to CXCR7 (unknown origin) expressed in CHO cell membranes incubated for 1 hr by radioligand displacement assay Inhibition of [125I]SDF-1alpha binding to CXCR7 (unknown origin) expressed in CHO cell membranes incubated for 1 hr by radioligand displacement assay	[PMID: 26042340]
HEK293	IC₅₀	0.084 μM Compound: FC131	Displacement of [125I]SDF-1alpha from CXCR4 expressed in HEK293 cell membrane after 1 hr Displacement of [125I]SDF-1alpha from CXCR4 expressed in HEK293 cell membrane after 1 hr	[PMID: 22352868]
HEK293	IC₅₀	1.2 μM Compound: 1a	Inhibition of [125I]SDF-1alpha binding to CXCR4 (unknown origin) expressed in HEK293 cell membranes incubated for 1 hr by radioligand displacement assay Inhibition of [125I]SDF-1alpha binding to CXCR4 (unknown origin) expressed in HEK293 cell membranes incubated for 1 hr by radioligand displacement assay	[PMID: 26042340]
HEK293	IC₅₀	126 nM Compound: 2, FC131	Displacement of [125I]-SDF-1alpha from CXCR4 receptor expressed in HEK293 cells after 1 hr by scintillation counting Displacement of [125I]-SDF-1alpha from CXCR4 receptor expressed in HEK293 cells after 1 hr by scintillation counting	[PMID: 24900333]
HeLa	EC₅₀	21 nM Compound: 2, FC131	Antiviral activity against Human immunodeficiency virus 1 NL4.3 infected in human HeLa cells assessed as inhibition of viral replication after 48 hrs by MAGI assay Antiviral activity against Human immunodeficiency virus 1 NL4.3 infected in human HeLa cells assessed as inhibition of viral replication after 48 hrs by MAGI assay	[PMID: 24900333]
HeLa	EC₅₀	21 nM Compound: 2, FC131	Antiviral activity against Human immunodeficiency virus 1 3B infected in human HeLa cells assessed as inhibition of viral replication after 48 hrs by MAGI assay Antiviral activity against Human immunodeficiency virus 1 3B infected in human HeLa cells assessed as inhibition of viral replication after 48 hrs by MAGI assay	[PMID: 24900333]

Molecular Weight

729.83

Formula

C₃₆H₄₇N₁₁O₆

CAS No.

606968-52-9

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tamamura H, et al. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 [Content Brief]

FC131 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FC131606968-52-9FC 131FC-131CXCRHIVCXC chemokine receptorsC-X-C motif chemokine receptorsHuman immunodeficiency virusInhibitorinhibitorinhibit

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