2. Others Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Metabolic Enzyme/Protease Autophagy
  3. Isotope-Labeled Compounds PPAR Cytochrome P450 Autophagy
  4. Fenofibrate-d6

Fenofibrate-d6 is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

For research use only. We do not sell to patients.

Fenofibrate-d<sub>6</sub> Chemical Structure

Fenofibrate-d6 Chemical Structure

CAS No. : 1092484-56-4

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500 μg USD 150 In-stock
1 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Fenofibrate-d6:

Fenofibrate-d6 Related Antibodies

Top Publications Citing Use of Products

View All PPAR Isoform Specific Products:

View All Isoforms
PPARα PPARβ/δ PPARγ PPAR PPARδ

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

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Description

Fenofibrate-d6 is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

IC50 & Target

CYP2

 

CYP3

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fenofibrate-d6 Related Antibodies
Molecular Weight

366.87

Formula

C20H15D6ClO4
CAS No.
Unlabeled CAS

49562-28-9
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(C(OC(C)C)=O)(C([2H])([2H])[2H])C([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 15 mg/mL (40.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7258 mL 13.6288 mL 27.2576 mL
5 mM 0.5452 mL 2.7258 mL 5.4515 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7258 mL 13.6288 mL 27.2576 mL 68.1440 mL
5 mM 0.5452 mL 2.7258 mL 5.4515 mL 13.6288 mL
10 mM 0.2726 mL 1.3629 mL 2.7258 mL 6.8144 mL
15 mM 0.1817 mL 0.9086 mL 1.8172 mL 4.5429 mL
20 mM 0.1363 mL 0.6814 mL 1.3629 mL 3.4072 mL
25 mM 0.1090 mL 0.5452 mL 1.0903 mL 2.7258 mL
30 mM 0.0909 mL 0.4543 mL 0.9086 mL 2.2715 mL
40 mM 0.0681 mL 0.3407 mL 0.6814 mL 1.7036 mL
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Fenofibrate-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fenofibrate-d61092484-56-4Isotope-Labeled CompoundsPPARCytochrome P450AutophagyPeroxisome proliferator-activated receptorsCYPsInhibitorinhibitorinhibit

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