2. Induced Disease Models Products
  3. Nervous System Disease Models
  4. Parkinson's Disease Models
  5. Fenpropathrin

Fenpropathrin is a synthetic pyrethroid insecticide in agriculture. Fenpropathrin may induces parkinsonian symptoms progressively.

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Fenpropathrin Chemical Structure

Fenpropathrin Chemical Structure

CAS No. : 39515-41-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Fenpropathrin:

Fenpropathrin Related Antibodies

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1 Publications Citing Use of MCE Fenpropathrin

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Description

Fenpropathrin is a synthetic pyrethroid insecticide in agriculture. Fenpropathrin may induces parkinsonian symptoms progressively[1].
In Vivo

Fenpropathrin can be used in animal modeling to create Parkinson's syndrome models. Fenpropathrin is lipophilic, allowing it to cross the blood-brain barrier, and it is characterized by rapid metabolic clearance in mammals[1].

1. Induction of Parkinson's syndrome[1]
Background
Fenpropathrin can cause an increase in dopamine transporter (DAT) levels and a decrease in vesicular monoamine transporter 2 (VMAT2) levels, which raises the cytoplasmic concentration of dopamine, worsening the damage to dopamine neurons and leading to Parkinson's syndrome.
Specific Mmodeling Methods
Rat: Sprague-Dawley (SD) • male
Administration: 15 mg/kg, i.p. • 1 μL of 6 μg/μL Fenpropathrin solution, stereotaxical infusion • once daily for 60 days
Note
(1) When injected into the abdominal cavity, Fenpropathrin is dissolved in corn oil; during the ST infusion, Fenpropathrin is dissolved in DMSO, with an injection volume of 1 μL.
(2) Half of the rats did not receive any treatment within 60 days after the last injection of Fenpropathrin, while the other half of the rats were euthanized 24 hours after the last Fenpropathrin treatment.
(3) For ST infusion, Fenpropathrin solution was injected into the right ventral tegmental area and substantia nigra pars compacta (SNc) at a flow rate of 0.2 μ L/min. After injection, the needle was left in place for 5 minutes to allow the drug to fully diffuse, and then the needle was slowly removed.
(4) Measure the levels of dopamine, DOPAC, and HVA in the striatum using HPLC.
(5) Slice the brain tissue into 15 μm thick sections using a low-temperature cryostat to analyze the immunoreactivity of DAT and VMAT2.
Modeling Indicators
Molecular changes: Tyrosine hydroxylase (TH) and vesicular monoamine transporter 2 (VMAT2) show reduced immune reactivity, while dopamine transporter (DAT) immune reactivity increases; the levels of dopamine, DOPCA, and HVA in the body decrease.
Behavioral observation: After 4 weeks of treatment, there was a decrease in movement activity, less climbing, reduced escape behavior, and slower movement.
Correlated Product(s): /
Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

349.42

Formula

C22H23NO3
CAS No.
Appearance

<47°C Solid,>47°C Liquid

Color

White to off-white

SMILES

O=C(C1C(C)(C)C1(C)C)OC(C#N)C2=CC=CC(OC3=CC=CC=C3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (286.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8619 mL 14.3094 mL 28.6189 mL
5 mM 0.5724 mL 2.8619 mL 5.7238 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.15 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
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% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.86%

COA (257 KB) HNMR (255 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8619 mL 14.3094 mL 28.6189 mL 71.5471 mL
5 mM 0.5724 mL 2.8619 mL 5.7238 mL 14.3094 mL
10 mM 0.2862 mL 1.4309 mL 2.8619 mL 7.1547 mL
15 mM 0.1908 mL 0.9540 mL 1.9079 mL 4.7698 mL
20 mM 0.1431 mL 0.7155 mL 1.4309 mL 3.5774 mL
25 mM 0.1145 mL 0.5724 mL 1.1448 mL 2.8619 mL
30 mM 0.0954 mL 0.4770 mL 0.9540 mL 2.3849 mL
40 mM 0.0715 mL 0.3577 mL 0.7155 mL 1.7887 mL
50 mM 0.0572 mL 0.2862 mL 0.5724 mL 1.4309 mL
60 mM 0.0477 mL 0.2385 mL 0.4770 mL 1.1925 mL
80 mM 0.0358 mL 0.1789 mL 0.3577 mL 0.8943 mL
100 mM 0.0286 mL 0.1431 mL 0.2862 mL 0.7155 mL
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Fenpropathrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fenpropathrin39515-41-8OthersInhibitorinhibitorinhibit

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