2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Fipronil sulfone

Fipronil sulfone is the major metabolite of Fipronil.Fipronil sulfone selectively inhibits GABA receptor with IC50 of 175 nM (assayed by displacement of 4′-ethynyl-4-n-[2,3-3H2]- propylbicycloorthobenzoate ([3H]EBOB) from the noncompetitive blocker site).

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Fipronil sulfone Chemical Structure

Fipronil sulfone Chemical Structure

CAS No. : 120068-36-2

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Fipronil sulfone Related Antibodies

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Description

Fipronil sulfone is the major metabolite of Fipronil.Fipronil sulfone selectively inhibits GABA receptor with IC50 of 175 nM (assayed by displacement of 4′-ethynyl-4-n-[2,3-3H2]- propylbicycloorthobenzoate ([3H]EBOB) from the noncompetitive blocker site).

Molecular Weight

453.15

Formula

C12H4Cl2F6N4O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=NN(C(N)=C1S(=O)(C(F)(F)F)=O)C2=C(C=C(C=C2Cl)C(F)(F)F)Cl
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (275.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2068 mL 11.0339 mL 22.0677 mL
5 mM 0.4414 mL 2.2068 mL 4.4135 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2068 mL 11.0339 mL 22.0677 mL 55.1694 mL
5 mM 0.4414 mL 2.2068 mL 4.4135 mL 11.0339 mL
10 mM 0.2207 mL 1.1034 mL 2.2068 mL 5.5169 mL
15 mM 0.1471 mL 0.7356 mL 1.4712 mL 3.6780 mL
20 mM 0.1103 mL 0.5517 mL 1.1034 mL 2.7585 mL
25 mM 0.0883 mL 0.4414 mL 0.8827 mL 2.2068 mL
30 mM 0.0736 mL 0.3678 mL 0.7356 mL 1.8390 mL
40 mM 0.0552 mL 0.2758 mL 0.5517 mL 1.3792 mL
50 mM 0.0441 mL 0.2207 mL 0.4414 mL 1.1034 mL
60 mM 0.0368 mL 0.1839 mL 0.3678 mL 0.9195 mL
80 mM 0.0276 mL 0.1379 mL 0.2758 mL 0.6896 mL
100 mM 0.0221 mL 0.1103 mL 0.2207 mL 0.5517 mL
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Fipronil sulfone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fipronil sulfone120068-36-2GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptormetaboliteInhibitorinhibitorinhibit

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