Fluorobexarotene

Cat. No.: HY-108525 Purity: 97.50%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a K_i value of 12 nM and an EC₅₀ value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.

For research use only. We do not sell to patients.

Fluorobexarotene Chemical Structure

CAS No. : 1190848-23-7

Size	Price	Stock	Quantity
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 850	Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

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RXRα RXRβ RXRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

366.47

Formula

C₂₄H₂₇FO₂

CAS No.

1190848-23-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(C(C2=C(C)C=C3C(C)(C)CCC(C)(C)C3=C2)=C)C=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 36 mg/mL (98.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7287 mL	13.6437 mL	27.2874 mL
5 mM	0.5457 mL	2.7287 mL	5.4575 mL
10 mM	0.2729 mL	1.3644 mL	2.7287 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.23%

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Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (226 KB) RP-HPLC (121 KB)

Handling Instructions (2659 KB)

References

[1]. Wagner CE, et al. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J Med Chem. 2009 Oct [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7287 mL	13.6437 mL	27.2874 mL	68.2184 mL
	5 mM	0.5457 mL	2.7287 mL	5.4575 mL	13.6437 mL
	10 mM	0.2729 mL	1.3644 mL	2.7287 mL	6.8218 mL
	15 mM	0.1819 mL	0.9096 mL	1.8192 mL	4.5479 mL
	20 mM	0.1364 mL	0.6822 mL	1.3644 mL	3.4109 mL
	25 mM	0.1091 mL	0.5457 mL	1.0915 mL	2.7287 mL
	30 mM	0.0910 mL	0.4548 mL	0.9096 mL	2.2739 mL
	40 mM	0.0682 mL	0.3411 mL	0.6822 mL	1.7055 mL
	50 mM	0.0546 mL	0.2729 mL	0.5457 mL	1.3644 mL
	60 mM	0.0455 mL	0.2274 mL	0.4548 mL	1.1370 mL
	80 mM	0.0341 mL	0.1705 mL	0.3411 mL	0.8527 mL