2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Fmoc-D-Val-D-Cit-PAB

Fmoc-D-Val-D-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC).

For research use only. We do not sell to patients.

Fmoc-D-Val-D-Cit-PAB Chemical Structure

Fmoc-D-Val-D-Cit-PAB Chemical Structure

CAS No. : 1350456-69-7

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25 mg USD 226 In-stock
50 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Fmoc-D-Val-D-Cit-PAB:

Fmoc-D-Val-D-Cit-PAB Related Antibodies

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Description

Fmoc-D-Val-D-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC)[1].

IC50 & Target

Protease Cleavable Linker

 

Molecular Weight

601.69

Formula

C33H39N5O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC(C=C1)=CC=C1NC([C@@H](CCCNC(N)=O)NC([C@@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (166.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6620 mL 8.3099 mL 16.6199 mL
5 mM 0.3324 mL 1.6620 mL 3.3240 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6620 mL 8.3099 mL 16.6199 mL 41.5496 mL
5 mM 0.3324 mL 1.6620 mL 3.3240 mL 8.3099 mL
10 mM 0.1662 mL 0.8310 mL 1.6620 mL 4.1550 mL
15 mM 0.1108 mL 0.5540 mL 1.1080 mL 2.7700 mL
20 mM 0.0831 mL 0.4155 mL 0.8310 mL 2.0775 mL
25 mM 0.0665 mL 0.3324 mL 0.6648 mL 1.6620 mL
30 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3850 mL
40 mM 0.0415 mL 0.2077 mL 0.4155 mL 1.0387 mL
50 mM 0.0332 mL 0.1662 mL 0.3324 mL 0.8310 mL
60 mM 0.0277 mL 0.1385 mL 0.2770 mL 0.6925 mL
80 mM 0.0208 mL 0.1039 mL 0.2077 mL 0.5194 mL
100 mM 0.0166 mL 0.0831 mL 0.1662 mL 0.4155 mL
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Fmoc-D-Val-D-Cit-PAB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-D-Val-D-Cit-PAB1350456-69-7ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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