2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Fmoc-GGFG-DXd

Fmoc-GGFG-DXd is a drug-linker conjugate for ADC. Fmoc-GGFG-DXd contains a ADC linker Fmoc-GGFG and a DNA topoisomerase I inhibitor DXd (HY-13631D).

For research use only. We do not sell to patients.

Fmoc-GGFG-DXd Chemical Structure

Fmoc-GGFG-DXd Chemical Structure

CAS No. : 1599440-11-5

Size Price Stock Quantity
5 mg USD 480 In-stock
10 mg USD 765 In-stock
25 mg USD 1500 In-stock
50 mg USD 2300 In-stock
100 mg USD 3550 In-stock
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

Fmoc-GGFG-DXd Related Antibodies

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View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Description

Fmoc-GGFG-DXd is a drug-linker conjugate for ADC. Fmoc-GGFG-DXd contains a ADC linker Fmoc-GGFG and a DNA topoisomerase I inhibitor DXd (HY-13631D)[1].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

Molecular Weight

1063.09

Formula

C57H55FN8O12
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(OCC1C2=CC=CC=C2C3=CC=CC=C31)NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(NCOCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (164.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9407 mL 4.7033 mL 9.4065 mL
5 mM 0.1881 mL 0.9407 mL 1.8813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9407 mL 4.7033 mL 9.4065 mL 23.5164 mL
5 mM 0.1881 mL 0.9407 mL 1.8813 mL 4.7033 mL
10 mM 0.0941 mL 0.4703 mL 0.9407 mL 2.3516 mL
15 mM 0.0627 mL 0.3136 mL 0.6271 mL 1.5678 mL
20 mM 0.0470 mL 0.2352 mL 0.4703 mL 1.1758 mL
25 mM 0.0376 mL 0.1881 mL 0.3763 mL 0.9407 mL
30 mM 0.0314 mL 0.1568 mL 0.3136 mL 0.7839 mL
40 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5879 mL
50 mM 0.0188 mL 0.0941 mL 0.1881 mL 0.4703 mL
60 mM 0.0157 mL 0.0784 mL 0.1568 mL 0.3919 mL
80 mM 0.0118 mL 0.0588 mL 0.1176 mL 0.2940 mL
100 mM 0.0094 mL 0.0470 mL 0.0941 mL 0.2352 mL
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Fmoc-GGFG-DXd Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-GGFG-DXd1599440-11-5 Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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