Folic acid-¹³C₆  (Synonyms: Vitamin B9-¹³C₆; Vitamin M-¹³C₆)

Folic acid-13C6 is a deuterated labeled Folic acid^[1]. Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency^[2][3][4][5].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
Folic acid plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Folic acid plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA^[2].

Folic acid (10, 50, 100 mg/kg; p.o.) shows an antidepressant-like effect in this behavioral mouse model^[3].
Folic acid (1, 10 nmol/site) shows no psychostimulant effect in mice habituated to the novel environment^[3].
Folic acid (1, 5 mg/kg; p.o.) prevents epigenetic modification of hepatic gene expression in the offspring in rats^[4].When folic acid was administrated orally as aqueous solution in rat, the AUC was 1.4 μg h/mL and oral bioavailability is 35%^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

447.35

C₁₃¹³C₆H₁₉N₇O₆

161406-20-8

59-30-3

O=C1C2=NC(CN[13C]3=[13CH][13CH]=[13C]([13CH]=[13CH]3)C(N[C@H](C(O)=O)CCC(O)=O)=O)=CNC2=NC(N)=N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8.  [Content Brief]

  [3]. Peñalva R, et al. Zein nanoparticles for oral folic acid delivery[J]. Journal of Drug Delivery Science and Technology, 2015, 30: 450-457.

  [4]. Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73.  [Content Brief]

  [5]. Aparicio-Trejo OE, et al. Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med. 2020 Jul;154:18-32.  [Content Brief]

  [6]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6.  [Content Brief]

  [7]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48.  [Content Brief]