Folic acid sodium (Synonyms: Vitamin B9 sodium; Vitamin M sodium)

Cat. No.: HY-16637A: FAQs
Data Sheet Handling Instructions

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Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.

For research use only. We do not sell to patients.

Folic acid sodium Chemical Structure

CAS No. : 6484-89-5

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Other In-stock Forms of Folic acid sodium:

Folic acid

Other Forms of Folic acid sodium:

Folic acid In-stock
Folcysteine Get quote
Folic acid disodium Get quote

8 Publications Citing Use of MCE Folic acid sodium

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	0.5 μM Compound: folic acid	Photocytotoxicity against human KB cells overexpressing folate receptor assessed as cell viability incubated for 24 hrs followed by halogen light illumination measured after 20 mins by MTT assay Photocytotoxicity against human KB cells overexpressing folate receptor assessed as cell viability incubated for 24 hrs followed by halogen light illumination measured after 20 mins by MTT assay	[PMID: 24088087]

In Vitro

Folic acid sodium plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Folic acid sodium (10, 50, 100 mg/kg; p.o.) shows an antidepressant-like effect in this behavioral mouse model^[2].
Folic acid sodium (1, 10 nmol/site) shows no psychostimulant effect in mice habituated to the novel environment^[2].
Folic acid sodium (1, 5 mg/kg; p.o.) prevents epigenetic modification of hepatic gene expression in the offspring in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	30-40 g swiss mice^[2]
Dosage:	10, 50, 100 mg/kg
Administration:	Oral administration
Result:	Decreased the immobility time in the forced swimming test (FST) (F₃₂₄=11.21) and produced a significant effect in the immobility time in the tail suspension test (TST) (F_3,20=5.71).

Animal Model:	30-40 g swiss mice^[2]
Dosage:	1-10 nmol/site
Administration:	Intracerebroventrical injection
Result:	Decreased the immobility time of mice in the FST (F_3,22=12.31) and TST (F_3,22=5.50).

Animal Model:	Virgin female Wistar rats^[3]
Dosage:	1, 5 mg/kg (180 g/kg protein with 1 mg/kg folic acid or 90 g/kg casein with 1, 5 mg/kg folic acid)
Administration:	Oral administration
Result:	Prevented epigenetic modification of hepatic gene expression in the offspring.

Clinical Trial

Molecular Weight

464.39

Formula

C₁₉H₁₉N₇NaO₆

CAS No.

6484-89-5

SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O.[Na]

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (215.34 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1534 mL	10.7668 mL	21.5336 mL
5 mM	0.4307 mL	2.1534 mL	4.3067 mL
10 mM	0.2153 mL	1.0767 mL	2.1534 mL

View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8. [Content Brief]

[2]. Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73. [Content Brief]

[3]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6. [Content Brief]

[4]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.1534 mL	10.7668 mL	21.5336 mL	53.8341 mL
	5 mM	0.4307 mL	2.1534 mL	4.3067 mL	10.7668 mL
	10 mM	0.2153 mL	1.0767 mL	2.1534 mL	5.3834 mL
	15 mM	0.1436 mL	0.7178 mL	1.4356 mL	3.5889 mL
	20 mM	0.1077 mL	0.5383 mL	1.0767 mL	2.6917 mL
	25 mM	0.0861 mL	0.4307 mL	0.8613 mL	2.1534 mL
	30 mM	0.0718 mL	0.3589 mL	0.7178 mL	1.7945 mL
	40 mM	0.0538 mL	0.2692 mL	0.5383 mL	1.3459 mL
	50 mM	0.0431 mL	0.2153 mL	0.4307 mL	1.0767 mL
	60 mM	0.0359 mL	0.1794 mL	0.3589 mL	0.8972 mL
	80 mM	0.0269 mL	0.1346 mL	0.2692 mL	0.6729 mL
	100 mM	0.0215 mL	0.1077 mL	0.2153 mL	0.5383 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Folic acid sodium Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Folic acid6484-89-5Vitamin B9Vitamin MVitamin B 9Vitamin B-9DNA/RNA SynthesisEndogenous Metabolitenutrientntidepressant-likeneural tube defectsfolic deficiencyInhibitorinhibitorinhibit

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