Folinic acid-d₄ calcium hydrate  (Synonyms: Leucovorin-d₄ calcium hydrate)

Folinic acid-d₄-1 (Leucovorin-d₄-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₀H₁₇D₄CaN₇O₇.xH₂O

58-05-9

Solid

White to off-white

O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(NC([2H])([2H])C2([2H])N(C=O)C3=C(NC(N)=NC3=O)NC2[2H])C=C1)=O.[F,Cl,Br,I].O.[Ca+2]

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.  [Content Brief]

  [3]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.  [Content Brief]