2. Apoptosis
  3. Ferroptosis
  4. FSEN1

FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer.

For research use only. We do not sell to patients.

FSEN1 Chemical Structure

FSEN1 Chemical Structure

CAS No. : 862808-01-3

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1 mg USD 36 In-stock
5 mg USD 125 In-stock
10 mg USD 200 In-stock
25 mg USD 400 In-stock
50 mg USD 640 In-stock
100 mg USD 990 In-stock
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Based on 1 publication(s) in Google Scholar

FSEN1 Related Antibodies

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  • Purity & Documentation

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Description

FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer[1].

In Vitro

FSEN1 (0-15 µM; H460C Cas9 cells) is synthetic lethal with GPX4 inhibitors and sensitizes cancer cells to ferroptosis through inhibition of FSP1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FSEN1 Related Antibodies
Molecular Weight

484.41

Formula

C22H22BrN5OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

BrC1=CC=C(C2=NN=C3SC(CN4CCN(CC4)C5=CC=C(C=C5)OC)=CN32)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 1 mg/mL (2.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0644 mL 10.3218 mL 20.6437 mL
5 mM 0.4129 mL 2.0644 mL 4.1287 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.56%

COA (254 KB) HNMR (262 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / DMSO 1 mM 2.0644 mL 10.3218 mL 20.6437 mL 51.6092 mL
DMSO 5 mM 0.4129 mL 2.0644 mL 4.1287 mL 10.3218 mL
10 mM 0.2064 mL 1.0322 mL 2.0644 mL 5.1609 mL
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FSEN1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSEN1862808-01-3FSEN 1FSEN-1Ferroptosisiron deathcancerH460C Cas9 cellsInhibitorinhibitorinhibit

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