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  3. Amino Acid Derivatives
  4. Fudosteine

Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression.

For research use only. We do not sell to patients.

Fudosteine Chemical Structure

Fudosteine Chemical Structure

CAS No. : 13189-98-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 58 In-stock
Solid
100 mg USD 53 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression[1][2].

In Vitro

Fudosteine (50, 100, 200 mg/kg) decreases the LPS-induced p-ERK1/2 and p-p38 MAPK levels in the rat lungs. The TNF-α-induced increase in MUC5AC mRNA expression is inhibited by pretreatment with 1 mM Fudosteine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

179.24

Formula

C6H13NO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CSCCCO)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (557.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5791 mL 27.8956 mL 55.7911 mL
5 mM 1.1158 mL 5.5791 mL 11.1582 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (278.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: ≥98.0%

Data Sheet (269 KB) SDS (393 KB)

COA (243 KB) HNMR (234 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5791 mL 27.8956 mL 55.7911 mL 139.4778 mL
5 mM 1.1158 mL 5.5791 mL 11.1582 mL 27.8956 mL
10 mM 0.5579 mL 2.7896 mL 5.5791 mL 13.9478 mL
15 mM 0.3719 mL 1.8597 mL 3.7194 mL 9.2985 mL
20 mM 0.2790 mL 1.3948 mL 2.7896 mL 6.9739 mL
25 mM 0.2232 mL 1.1158 mL 2.2316 mL 5.5791 mL
30 mM 0.1860 mL 0.9299 mL 1.8597 mL 4.6493 mL
40 mM 0.1395 mL 0.6974 mL 1.3948 mL 3.4869 mL
50 mM 0.1116 mL 0.5579 mL 1.1158 mL 2.7896 mL
60 mM 0.0930 mL 0.4649 mL 0.9299 mL 2.3246 mL
80 mM 0.0697 mL 0.3487 mL 0.6974 mL 1.7435 mL
100 mM 0.0558 mL 0.2790 mL 0.5579 mL 1.3948 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fudosteine Related Classifications

Keywords:

Fudosteine13189-98-5Amino Acid DerivativesMUC5ACmRNAmucoactivecysteinederivativeInhibitorinhibitorinhibit

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