2. Anti-infection
  3. Bacterial
  4. Furanone C-30

Furanone C-30 is a quorum sensing inhibitor. Furanone C-30 can effectively inhibit bacterial biofilm formation by S. mutans and its luxSmutant strain.

For research use only. We do not sell to patients.

Furanone C-30 Chemical Structure

Furanone C-30 Chemical Structure

CAS No. : 247167-54-0

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1 mg USD 85 In-stock
5 mg USD 170 In-stock
10 mg USD 270 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Furanone C-30 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Furanone C-30

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Furanone C-30 is a quorum sensing inhibitor. Furanone C-30 can effectively inhibit bacterial biofilm formation by S. mutans and its luxSmutant strain[1].

IC50 & Target

Bacterial biofilm[1]
In Vitro

The difference in the OD590 values is statistically significant at concentrations of 2.0 μg/mL and 4.0 μg/mL compared with the control group. Furanone C-30 (2.0 μg/mL and 4.0 μg/mL) can inhibit biofilm formation by S. mutans and its luxS mutant strain, although it does not affect the bacterial growth rate itself[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Furanone C-30 Related Antibodies

Cell Viability Assay[1]

Cell Line: Streptococcus mutans UA159 and its luxS mutant strain
Concentration: 0.0, 2.0 and 4.0 μg/mL
Incubation Time: 24 hours
Result: When 2.0 μg/mL was added, the OD590 values for S. mutans and its luxS mutant strain decreased by 42.7% and 40.8%, respectively. When the concentration was increased to 4.0 μg/mL, a decrease of 61.5% and 60.3%, respectively.
Molecular Weight

253.88

Formula

C5H2Br2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C=C/1Br)OC1=C/Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (393.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9389 mL 19.6943 mL 39.3887 mL
5 mM 0.7878 mL 3.9389 mL 7.8777 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (9.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

COA (255 KB) HNMR (122 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9389 mL 19.6943 mL 39.3887 mL 98.4717 mL
5 mM 0.7878 mL 3.9389 mL 7.8777 mL 19.6943 mL
10 mM 0.3939 mL 1.9694 mL 3.9389 mL 9.8472 mL
15 mM 0.2626 mL 1.3130 mL 2.6259 mL 6.5648 mL
20 mM 0.1969 mL 0.9847 mL 1.9694 mL 4.9236 mL
25 mM 0.1576 mL 0.7878 mL 1.5755 mL 3.9389 mL
30 mM 0.1313 mL 0.6565 mL 1.3130 mL 3.2824 mL
40 mM 0.0985 mL 0.4924 mL 0.9847 mL 2.4618 mL
50 mM 0.0788 mL 0.3939 mL 0.7878 mL 1.9694 mL
60 mM 0.0656 mL 0.3282 mL 0.6565 mL 1.6412 mL
80 mM 0.0492 mL 0.2462 mL 0.4924 mL 1.2309 mL
100 mM 0.0394 mL 0.1969 mL 0.3939 mL 0.9847 mL
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Furanone C-30 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Furanone C-30247167-54-0Furanone C30Furanone C 30BacterialInhibitorinhibitorinhibit

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