2. Metabolic Enzyme/Protease
  3. Factor Xa Thrombin
  4. FXIIa-IN-4

FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC50 of 0.032 μM, 0.30 μM, ＞50 μM for FXIIa, thrombin and FXIa, respectively. FXIIa-IN-4 can be used for study of anticoagulant.

For research use only. We do not sell to patients.

FXIIa-IN-4 Chemical Structure

FXIIa-IN-4 Chemical Structure

Size Price Stock Quantity
5 mg USD 140 In-stock
10 mg USD 220 In-stock
25 mg USD 460 In-stock
50 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

FXIIa-IN-4 Related Antibodies

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Description

FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC50 of 0.032 μM, 0.30 μM, ＞50 μM for FXIIa, thrombin and FXIa, respectively. FXIIa-IN-4 can be used for study of anticoagulant[1].

Molecular Weight

264.21

Formula

C11H9FN4O3
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(C(C2=CC=C(F)C=C2)=O)C(N)=N1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 26.92 mg/mL (101.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7849 mL 18.9243 mL 37.8487 mL
5 mM 0.7570 mL 3.7849 mL 7.5697 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7849 mL 18.9243 mL 37.8487 mL 94.6217 mL
5 mM 0.7570 mL 3.7849 mL 7.5697 mL 18.9243 mL
10 mM 0.3785 mL 1.8924 mL 3.7849 mL 9.4622 mL
15 mM 0.2523 mL 1.2616 mL 2.5232 mL 6.3081 mL
20 mM 0.1892 mL 0.9462 mL 1.8924 mL 4.7311 mL
25 mM 0.1514 mL 0.7570 mL 1.5139 mL 3.7849 mL
30 mM 0.1262 mL 0.6308 mL 1.2616 mL 3.1541 mL
40 mM 0.0946 mL 0.4731 mL 0.9462 mL 2.3655 mL
50 mM 0.0757 mL 0.3785 mL 0.7570 mL 1.8924 mL
60 mM 0.0631 mL 0.3154 mL 0.6308 mL 1.5770 mL
80 mM 0.0473 mL 0.2366 mL 0.4731 mL 1.1828 mL
100 mM 0.0378 mL 0.1892 mL 0.3785 mL 0.9462 mL
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FXIIa-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FXIIa-IN-4Factor XaThrombinFxathromboembolic diseasesanticoagulantInhibitorinhibitorinhibit

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