GABAA receptor agent 1

Name: GABAA receptor agent 1
Brand: MedChemExpress
SKU: HY-133486
Rating: 4.5 (1 reviews)

Cat. No.: HY-133486 Purity: 98.93%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity.

For research use only. We do not sell to patients.

GABAA receptor agent 1 Chemical Structure

CAS No. : 1571-87-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 170	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 170	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 155	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 248	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 495	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 792	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1185	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity^[1].

In Vivo

GABAA receptor agent 1 (30 mg/kg; intraperitoneal) inhibits the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions in swiss albino rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

273.67

Formula

C₁₃H₈ClN₃O₂

CAS No.

1571-87-5

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=[N+](C1=CC=C2N=C(C3=CC=C(Cl)C=C3)NC2=C1)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (304.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6540 mL	18.2702 mL	36.5404 mL
5 mM	0.7308 mL	3.6540 mL	7.3081 mL
10 mM	0.3654 mL	1.8270 mL	3.6540 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.93%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (245 KB) HNMR (226 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Jain P, et al. Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity. Arch Pharm Res. 2010 Jul;33(7):971-80. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6540 mL	18.2702 mL	36.5404 mL	91.3509 mL
	5 mM	0.7308 mL	3.6540 mL	7.3081 mL	18.2702 mL
	10 mM	0.3654 mL	1.8270 mL	3.6540 mL	9.1351 mL
	15 mM	0.2436 mL	1.2180 mL	2.4360 mL	6.0901 mL
	20 mM	0.1827 mL	0.9135 mL	1.8270 mL	4.5675 mL
	25 mM	0.1462 mL	0.7308 mL	1.4616 mL	3.6540 mL
	30 mM	0.1218 mL	0.6090 mL	1.2180 mL	3.0450 mL
	40 mM	0.0914 mL	0.4568 mL	0.9135 mL	2.2838 mL
	50 mM	0.0731 mL	0.3654 mL	0.7308 mL	1.8270 mL
	60 mM	0.0609 mL	0.3045 mL	0.6090 mL	1.5225 mL
	80 mM	0.0457 mL	0.2284 mL	0.4568 mL	1.1419 mL
	100 mM	0.0365 mL	0.1827 mL	0.3654 mL	0.9135 mL