2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. Ganitumab

Ganitumab  (Synonyms: AMG 479; Human Anti-IGF1R Recombinant Antibody)

Cat. No.: HY-P99294 Purity: 96.00%
COA

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Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No. : 905703-97-1

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Based on 1 publication(s) in Google Scholar

Ganitumab Related Antibodies

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Description

Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
In Vitro

Ganitumab (AMG 479; 0.032-500 nM; 10 min; CT26 cells) binds mIGF1R and inhibits IGF1- and IGF2-mediated activation of mIGF1R[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ganitumab Related Antibodies

Western Blot Analysis[1]

Cell Line: CT26 cells
Concentration: 0.032-500 nM
Incubation Time: 10 minutes
Result: Inhibited IGF1-induced autophosphorylation of mIGF1R in CT26 murine colon carcinoma cells in a dose-dependent manner.
In Vivo

Ganitumab (AMG 479; 1 mg/dose; i.p; Naïve and tumor-bearing mice) inhibits IGF1-induced activation of mIGF1R in murine lungs[1].
Ganitumab (300 μg/dose; i.p.; female athymic nude mice) reduces peripheral blood neutrophils[1].
Ganitumab (300 μg/dose; i.p.; male athymic nude mice) causes impaired glucose tolerance in male mice and increases serum levels of mGH, mIGF1 and mIGFBP3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naïve and tumor-bearing mice[1]
Dosage: 1 mg/dose
Administration: Intraperitoneal injection
Result: Inhibited the IGF1-induced activation of mIGF1R and inhibited 80% tumor growth.
Animal Model: Male athymic nude mice[1]
Dosage: 300 μg/dose
Administration: Intraperitoneal injection, twice per week for a total of five doses
Result: Had significantly higher serum glucose levels than hIgG1-pretreated mice.
Increased serum levels of mIGF1, mIGFPB3 and mGH.
Animal Model: Female athymic nude mice[1]
Dosage: 300 μg/dose
Administration: Intraperitoneal injection, twice per week for a total of five doses
Result: Reduced the number of peripheral neutrophils up to 50% compared with hIgG1 controls.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ganitumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Ganitumab on AHC2 biosensor, can bind IGF-I R Protein, Human (HEK293, His-Avi, HY-P78458) with an affinity constant of 8.072E-10 M as determined in BLI assay.
Purity & Documentation

Purity: 96.00%

COA (232 KB) SDS-PAGE (89 KB) SEC-HPLC (140 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Ganitumab Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganitumab905703-97-1AMG 479 Human Anti-IGF1R Recombinant AntibodyAMG479AMG-479IGF-1RInsulin-like growth factor-1 receptormonoclonal antibodycancerIGF1IGF2Inhibitorinhibitorinhibit

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