2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. GDP-α-D-mannose disodium

GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM).

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GDP-α-D-mannose disodium Chemical Structure

GDP-α-D-mannose disodium Chemical Structure

CAS No. : 148296-46-2

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5 mg USD 400 In-stock
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Other Forms of GDP-α-D-mannose disodium:

GDP-α-D-mannose disodium Related Antibodies

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Description

GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

GDP-?α-D-?mannose is the alpha-anomer of GDP-D-mannose.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GDP-α-D-mannose disodium Related Antibodies
Molecular Weight

649.30

Formula

C16H23N5Na2O16P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(OP(O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)(O[Na])=O)(O[Na])OC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2N3C(N=C(N)NC4=O)=C4N=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (154.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5401 mL 7.7006 mL 15.4012 mL
5 mM 0.3080 mL 1.5401 mL 3.0802 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.76%

COA (252 KB) RP-HPLC (228 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5401 mL 7.7006 mL 15.4012 mL 38.5030 mL
5 mM 0.3080 mL 1.5401 mL 3.0802 mL 7.7006 mL
10 mM 0.1540 mL 0.7701 mL 1.5401 mL 3.8503 mL
15 mM 0.1027 mL 0.5134 mL 1.0267 mL 2.5669 mL
20 mM 0.0770 mL 0.3850 mL 0.7701 mL 1.9252 mL
25 mM 0.0616 mL 0.3080 mL 0.6160 mL 1.5401 mL
30 mM 0.0513 mL 0.2567 mL 0.5134 mL 1.2834 mL
40 mM 0.0385 mL 0.1925 mL 0.3850 mL 0.9626 mL
50 mM 0.0308 mL 0.1540 mL 0.3080 mL 0.7701 mL
60 mM 0.0257 mL 0.1283 mL 0.2567 mL 0.6417 mL
80 mM 0.0193 mL 0.0963 mL 0.1925 mL 0.4813 mL
100 mM 0.0154 mL 0.0770 mL 0.1540 mL 0.3850 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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GDP-α-D-mannose disodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GDP-α-D-mannose disodium148296-46-2Endogenous MetaboliteInhibitorinhibitorinhibit

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