2. Apoptosis Cell Cycle/DNA Damage Autophagy
  3. Apoptosis Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy
  4. Gemcitabine-13C,15N2 hydrochloride

Gemcitabine-13C,15N2 hydrochloride  (Synonyms: LY 188011-13C,15N2 hydrochloride)

Cat. No.: HY-B0003S Purity: 99.8%
COA Handling Instructions

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Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3].

For research use only. We do not sell to patients.

Gemcitabine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub> hydrochloride Chemical Structure

Gemcitabine-13C,15N2 hydrochloride Chemical Structure

CAS No. : 2757566-59-7

Size Price Stock Quantity
500 μg USD 418 In-stock

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Based on 1 publication(s) in Google Scholar

Other Forms of Gemcitabine-13C,15N2 hydrochloride:

Gemcitabine-13C,15N2 hydrochloride Related Antibodies

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Description

Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gemcitabine-13C,15N2 hydrochloride Related Antibodies
Molecular Weight

302.64

Formula

C813CH12ClF2N15N2O4
CAS No.
Unlabeled CAS

122111-03-9
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]([C@@H](O)C1(F)F)O[C@H]1[15N]2C=CC(N)=[15N][13C]2=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (206.52 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 25 mg/mL (82.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3043 mL 16.5213 mL 33.0426 mL
5 mM 0.6609 mL 3.3043 mL 6.6085 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.8%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.3043 mL 16.5213 mL 33.0426 mL 82.6064 mL
5 mM 0.6609 mL 3.3043 mL 6.6085 mL 16.5213 mL
10 mM 0.3304 mL 1.6521 mL 3.3043 mL 8.2606 mL
15 mM 0.2203 mL 1.1014 mL 2.2028 mL 5.5071 mL
20 mM 0.1652 mL 0.8261 mL 1.6521 mL 4.1303 mL
25 mM 0.1322 mL 0.6609 mL 1.3217 mL 3.3043 mL
30 mM 0.1101 mL 0.5507 mL 1.1014 mL 2.7535 mL
40 mM 0.0826 mL 0.4130 mL 0.8261 mL 2.0652 mL
50 mM 0.0661 mL 0.3304 mL 0.6609 mL 1.6521 mL
60 mM 0.0551 mL 0.2754 mL 0.5507 mL 1.3768 mL
80 mM 0.0413 mL 0.2065 mL 0.4130 mL 1.0326 mL
DMSO 100 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8261 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gemcitabine-13C,15N2 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gemcitabine-13C,15N22757566-59-7LY 188011-13C,15N2ApoptosisNucleoside Antimetabolite/AnalogDNA/RNA SynthesisAutophagyInhibitorinhibitorinhibit

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