TOM1L1 - target of myb1 like 1 membrane trafficking protein Gene

Homo sapiens

Also known as SRCASM

Gene ID: 10040 | Gene type: protein coding

About TOM1L1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:54,900,852-54,961,956 (from NCBI)

This gene has 23 transcripts (splice variants), 152 orthologues and 10 paralogues. Broad expression in duodenum (RPKM 37.8), thyroid (RPKM 25.7) and 24 other tissues.

Summary

Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome. [provided by Alliance of Genome Resources, Apr 2022]

TOM1L1 Products(5)

mRNA	Protein	Name
NM_001321173.2	NP_001308102.1	TOM1-like protein 1 isoform 2
NM_001321174.2	NP_001308103.1	TOM1-like protein 1 isoform 3
NM_001321175.2	NP_001308104.1	TOM1-like protein 1 isoform 3
NM_001321176.2	NP_001308105.1	TOM1-like protein 1 isoform 3
NM_005486.3	NP_005477.2	TOM1-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables clathrin binding	IDA IDA: Inferred from direct assay	16412388	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15611048	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16479011	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	16479011	GOA
involved in negative regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	16479011	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	16479011	GOA
NOT involved in regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16479011	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	16479011	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16412388	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15611048	GOA
located in endosome	IDA IDA: Inferred from direct assay	15611048	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOM1L1 Protein Structure

VHS

GAT

0
100
200
300
400
476 a.a.

Protein Preferred Names

Protein Names

TOM1-like protein 1

src-activating and signaling molecule protein

TOM1L1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TOM1L1	O75674	EGFR	Homo sapiens	P00533	Anti Bait CoIP	19798056
Intra	TOM1L1	O75674	VAV2	Homo sapiens	P52735	Y2H	18654987
Intra	TOM1L1	O75674	CLTC	Homo sapiens	Q00610	Pull Down	19798056
Intra	TOM1L1	O75674	GRB2	Homo sapiens	P62993	Pull Down	19798056
Intra	TOM1L1	O75674	GRB2	Homo sapiens	P62993	Anti Bait CoIP	19798056
Intra	TOM1L1	O75674	TOM1	Homo sapiens	O60784	Pull Down	19798056

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nodular Basal Cell Carcinoma

Basal Cell Carcinoma, Nodular	Circumscribed Solid Basal Cell Carcinoma
Skin Nodulo-Ulcerative Basal Cell Carcinoma	Skin Solid Basal Cell Carcinoma
Skin Nodular Basal Cell Carcinoma	Skin Nodular Solid Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Circumscribed Solid Basal Cell Carcinoma Of Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14877	TOM1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TOM1L1	VGNC	VGNC:36218
Canis familiaris	TOM1L1	VGNC	VGNC:47708
Rattus norvegicus	TOM1L1	RGD	RGD:1562626
Mus musculus	TOM1L1	MGD	MGI:1919193
Felis catus	TOM1L1	VGNC	VGNC:97667
Macaca mulatta	TOM1L1	VGNC	VGNC:78616

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