VAV2 - vav guanine nucleotide exchange factor 2 Gene

Homo sapiens

Also known as VAV-2

Gene ID: 7410 | Gene type: protein coding

About VAV2

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,761,894-133,992,324 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 22 paralogues. Ubiquitous expression in adrenal (RPKM 10.2), small intestine (RPKM 8.2) and 25 other tissues.

Summary

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

VAV2 Products(3)

mRNA	Protein	Name
NM_001134398.2	NP_001127870.1	guanine nucleotide exchange factor VAV2 isoform 1
NM_001411028.1	NP_001397957.1	guanine nucleotide exchange factor VAV2 isoform 3
NM_003371.4	NP_003362.2	guanine nucleotide exchange factor VAV2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	EXP EXP: Inferred from Experiment	8990121	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11390470	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of GTPase activity	IGI IGI: Inferred from genetic interaction	22467863	GOA
NOT involved in regulation of cell size	IGI IGI: Inferred from genetic interaction	22467863	GOA
involved in regulation of cell size	IGI IGI: Inferred from genetic interaction	22467863	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAV2 Protein Structure

CAMSAP_CH

RhoGEF

C1_1

SH3_2

SH2

SH3_2

0
200
400
600
800
878 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide exchange factor VAV2

vav 2 oncogene

VAV2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VAV2	P52735	NEK3	Homo sapiens	P51956	CoIP	15618286
Intra	VAV2	P52735	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	VAV2	P52735	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	20808760
Intra	VAV2	P52735	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	VAV2	P52735	TOM1L1	Homo sapiens	O75674	Anti Tag CoIP	18654987
Intra	VAV2	P52735	SH3BP2	Homo sapiens	P78314	Pull Down	11390470
Intra	VAV2	P52735	SH3BP2	Homo sapiens	P78314	Y2H	15345594
Intra	VAV2	P52735	SH3BP2	Homo sapiens	P78314	Pull Down	15345594
Intra	VAV2	P52735	SH3BP2	Homo sapiens	P78314	Anti Tag CoIP	15345594

Cross: Cross-species interaction Intra: Intraspecies interaction

VAV2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83567	VAV2 Antibody (YA3312)	WB, ICC/IF, IP	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12810	EHop-016	Inhibitor	99.85%	Unkown
HY-RS15613	VAV2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VAV2	VGNC	VGNC:78758
Felis catus	VAV2	VGNC	VGNC:66926
Mus musculus	VAV2	MGD	MGI:102718
Rattus norvegicus	VAV2	RGD	RGD:1306285
Canis familiaris	VAV2	VGNC	VGNC:58344
Bos taurus	VAV2	VGNC	VGNC:36773

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