RANBP9 - RAN binding protein 9 Gene

Homo sapiens

Also known as BPM-L; BPM90; RANBPM; RanBP7

Gene ID: 10048 | Gene type: protein coding

About RANBP9

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:13,621,498-13,711,835 (from NCBI)

This gene has 2 transcripts (splice variants), 233 orthologues and 3 paralogues. Broad expression in testis (RPKM 72.2), esophagus (RPKM 38.9) and 23 other tissues.

Summary

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the Ras superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several Other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, Androgen Receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]

RANBP9 Products(1)

mRNA	Protein	Name
NM_005493.3	NP_005484.2	ran-binding protein 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17087506	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12220523	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23118896	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15381419	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12220523	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	29911972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANBP9 Protein Structure

SPRY

LisH

CLTH

0
200
400
600
729 a.a.

Protein Preferred Names

Protein Names

ran-binding protein 9

Ran Binding Protein in the Microtubule organizing center

RANBP9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RANBP9	Q96S59	OPRM1	Homo sapiens	P35372	Y2H	23840749
Intra	RANBP9	Q96S59	OPRM1	Homo sapiens	P35372	Pull Down	23840749
Intra	RANBP9	Q96S59	S100A7	Homo sapiens	P31151	Y2H	12421467
Intra	RANBP9	Q96S59	PPP1CC	Homo sapiens	P36873-2	Y2H	21382349
Intra	RANBP9	Q96S59	DISC1	Homo sapiens	Q9NRI5	Y2H	12812986
Intra	RANBP9	Q96S59	DYRK1B	Homo sapiens	Q9Y463	Pull Down	14500717
Intra	RANBP9	Q96S59	ENTPD1	Homo sapiens	P49961	Anti Bait CoIP	16478441
Intra	RANBP9	Q96S59	ENTPD1	Homo sapiens	P49961	Anti Tag CoIP	16478441

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11649	RANBP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RANBP9	VGNC	VGNC:102500
Mus musculus	RANBP9	MGD	MGI:1928741
Canis familiaris	RANBP9	VGNC	VGNC:49679
Rattus norvegicus	RANBP9	RGD	RGD:1561940
Macaca mulatta	RANBP9	VGNC	VGNC:76475
Bos taurus	RANBP9	VGNC	VGNC:33712

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