Atg14 - autophagy related 14 Gene

Mus musculus

Also known as Atg14L; 4832427M01; D14Ertd114e; D14Ertd436e

Gene ID: 100504663 | Gene type: protein coding

About Atg14

Summary

Predicted to enable GTPase binding activity. Involved in autophagy; cellular response to glucose starvation; and regulation of protein phosphorylation. Acts upstream of or within regulation of triglyceride metabolic process. Located in axoneme; mitochondria-associated endoplasmic reticulum membrane; and phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Orthologous to human ATG14 (Autophagy related 14). [provided by Alliance of Genome Resources, Apr 2022]

Atg14 Products(1)

mRNA	Protein	Name
NM_172599.4	NP_766187.1	beclin 1-associated autophagy-related key regulator

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22797916	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagy	IMP IMP: Inferred from mutant phenotype	19270693	MGI
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	23332761	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	26764600	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	26764600	MGI
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	23332761	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	23332761	MGI
acts upstream of or within regulation of triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	22992773	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axoneme	IDA IDA: Inferred from direct assay	24089209	MGI
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	23455425	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	22493499	MGI
part of phosphatidylinositol 3-kinase complex, class III	IDA IDA: Inferred from direct assay	23332761	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beclin 1-associated autophagy-related key regulator

Atg14-like protein	VATG14 autophagy related 14 homolog
autophagy-related protein 14-like protein	barkor

Atg14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Atg14	Q8CDJ3	Nrbf2	Mus musculus	Q8VCQ3	Anti Bait CoIP	24849286
Intra	Atg14	Q8CDJ3	Nrbf2	Mus musculus	Q8VCQ3	Pull Down	24849286
Intra	Atg14	Q8CDJ3	Nrbf2	Mus musculus	Q8VCQ3	GMS	24849286
Intra	Atg14	Q8CDJ3	Nrbf2	Mus musculus	Q8VCQ3	Confocal	24849286
Intra	Atg14	Q8CDJ3	Nrbf2	Mus musculus	Q8VCQ3	Anti Tag CoIP	24849286

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145752	HaloPROTAC-E	Inhibitor	99.62%	Unkown
HY-156237	Beclin1-ATG14L interaction inhibitor 1	Inhibitor	99.88%	Unkown
HY-RS01142	ATG14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atg14	NCBI	NCBI:22863

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