SCAMP2 - secretory carrier membrane protein 2 Gene

Homo sapiens

Gene ID: 10066 | Gene type: protein coding

About SCAMP2

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,843,730-74,873,365 (from NCBI)

This gene has 12 transcripts (splice variants), 272 orthologues and 4 paralogues. Ubiquitous expression in colon (RPKM 41.0), small intestine (RPKM 37.7) and 25 other tissues.

Summary

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

SCAMP2 Products(2)

mRNA	Protein	Name
NM_001320778.2	NP_001307707.1	secretory carrier-associated membrane protein 2 isoform 1
NM_005697.5	NP_005688.2	secretory carrier-associated membrane protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15840657	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein transport	IDA IDA: Inferred from direct assay	15840657	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	15840657	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	15840657	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	15840657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAMP2 Protein Structure

SCAMP

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

secretory carrier-associated membrane protein 2

testis secretory sperm-binding protein Li 219p

SCAMP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCAMP2	O15127	SLC41A1	Homo sapiens	Q8IVJ1	Validated Y2H	32296183
Intra	SCAMP2	O15127	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	SCAMP2	O15127	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	SCAMP2	O15127	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 15q24 Deletion Syndrome

15q24 Microdeletion Syndrome	Del(15)(Q24)
Monosomy 15q24	15q24 Microdeletion
15q24 Deletion	Interstitial Deletion Of Chromosome 15q24

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12479	SCAMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SCAMP2	VGNC	VGNC:64896
Macaca mulatta	SCAMP2	VGNC	VGNC:76974
Bos taurus	SCAMP2	VGNC	VGNC:34316
Rattus norvegicus	SCAMP2	RGD	RGD:68348
Mus musculus	SCAMP2	MGD	MGI:1346518
Canis familiaris	SCAMP2	VGNC	VGNC:45891

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