2. Gene
  3. SLC41A1 - solute carrier family 41 member 1 Gene

SLC41A1 - solute carrier family 41 member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MgtE; NPHPL2

Gene ID: 254428 | Gene type: protein coding

About SLC41A1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,789,095-205,813,198 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in heart (RPKM 55.1), testis (RPKM 27.0) and 20 other tissues.

Summary

Enables magnesium ion transmembrane transporter activity and magnesium:sodium antiporter activity. Involved in cellular magnesium ion homeostasis; cellular response to magnesium ion; and magnesium ion transmembrane transport. Located in basolateral plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

SLC41A1 Products(1)

mRNA Protein Name
NM_173854.6 NP_776253.3 solute carrier family 41 member 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables magnesium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
18367447 GOA
enables magnesium:sodium antiporter activity IMP
IMP: Inferred from mutant phenotype
22031603 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables transmembrane transporter activity IDA
IDA: Inferred from direct assay
23661805 GOA
enables transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
22031603 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to magnesium ion IGI
IGI: Inferred from genetic interaction
21696366 GOA
involved in intracellular magnesium ion homeostasis IMP
IMP: Inferred from mutant phenotype
22031603 GOA
involved in magnesium ion transmembrane transport IDA
IDA: Inferred from direct assay
18367447 GOA
involved in magnesium ion transport IDA
IDA: Inferred from direct assay
18367447 GOA
involved in magnesium ion transport IMP
IMP: Inferred from mutant phenotype
22031603 GOA
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
23661805 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18367447 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
18367447 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC41A1 Protein Structure

MgtE

MgtE: Divalent cation transporter (139 - 270)

MgtE

MgtE: Divalent cation transporter (352 - 498)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
Protein Preferred Names Protein Names

solute carrier family 41 member 1

solute carrier family 41 (magnesium transporter), member 1

Related Diseases

Diseases Alias
Nephronophthisis-Like Nephropathy 2

NPHPL2
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

XMEN

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia

Cid Due To Magt1 Deficiency

Combined Immunodeficiency Due To Magt1 Deficiency

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An

X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Cystic Kidney Disease

Renal Cyst

Simple Renal Cyst

Kidney Cysts

Kidney Diseases, Cystic

Renal Cysts

Kidney Cyst

Cystic Kidney

Congenital Cystic Kidney Disease

Cystic Kidney Diseases

Bosniak 1 Cyst
Hypomagnesemia 1, Intestinal

Intestinal Hypomagnesemia 1

HOMG1

Hypomagnesemia With Secondary Hypocalcemia

Hsh

Hypomagnesemic Tetany

Intestinal Hypomagnesemia With Secondary Hypocalcemia

Homg

Hypomagnesemia Caused By Selective Magnesium Malabsorption

Hypomagnesemia Intestinal Type 1

Primary Hypomagnesemia With Secondary Hypocalcemia

Phsh

Hypomagnesemia, Intestinal, With Secondary Hypocalcemia

Familial Primary Hypomagnesemia With Hypocalcuria

Hypomagnesemia 1

Hypomagnesmic Tetany
Urofacial Syndrome 1

Urofacial Syndrome

Ochoa Syndrome

Hydronephrosis With Peculiar Facial Expression

Ufs

Inverted Smile And Occult Neuropathic Bladder

Partial Facial Palsy With Urinary Abnormalities

UFS1

Urofacial Ochoa'S Syndrome

Urofacial Syndrome Type 1

Facial Palsy, Partial, With Urinary Abnormalities

Hydronephrosis-Inverted Smile

Inverted Smile-Neurogenic Bladder

Hydronephrosis-Inverted Smile Syndrome

Inverted Smile-Neurogenic Bladder Syndrome

Partial Facial Palsy Partial With Urinary Abnormalities

Urologic Diseases
Primary Hypomagnesemia

Familial Primary Hypomagnesemia

Homg

Primary Familial Hypomagnesemia

Genetic Primary Hypomagnesemia

Hypomagnesemia 1, Intestinal
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13246 SLC41A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC41A1 VGNC VGNC:34873
Canis familiaris SLC41A1 VGNC VGNC:46412
Macaca mulatta SLC41A1 VGNC VGNC:77515
Rattus norvegicus SLC41A1 RGD RGD:1311397
Mus musculus SLC41A1 MGD MGI:2444823
Felis catus SLC41A1 VGNC VGNC:65368