ACTR3 - actin related protein 3 Gene

Homo sapiens

Also known as ARP3

Gene ID: 10096 | Gene type: protein coding

About ACTR3

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,889,934-113,962,596 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 26 paralogues. Ubiquitous expression in lymph node (RPKM 65.6), appendix (RPKM 59.7) and 24 other tissues.

Summary

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

ACTR3 Products(2)

mRNA	Protein	Name
NM_001277140.1	NP_001264069.1	actin-related protein 3 isoform 2
NM_005721.5	NP_005712.1	actin-related protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to actin filament binding	IDA IDA: Inferred from direct assay	11741539	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	11741539	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	11741539	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	20393563	GOA
involved in positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	29058690	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17220302	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Arp2/3 protein complex	IDA IDA: Inferred from direct assay	11741539	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17220302	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	9230079	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16767080	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACTR3 Protein Structure

Actin

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

actin-related protein 3

ARP3 actin related protein 3 homolog

Recombinant ACTR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76733	ARP3/ACTR3 Protein, Human (sf9, His-GST)	P61158 (A2-S418)	≥95%

Related Diseases

Diseases

Alias

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Colorectal Cancer, Hereditary Nonpolyposis, Type 2

HNPCC2	Fcc2
Coca2	Hereditary Nonpolyposis Colorectal Cancer Type 2
Colon Cancer, Familial Nonpolyposis, Type 2	Familial Nonpolyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colorectal Cancer 2	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00231	ACTR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00232	ACTR3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ACTR3	VGNC	VGNC:50033
Felis catus	ACTR3	VGNC	VGNC:59557
Macaca mulatta	ACTR3	VGNC	VGNC:69436
Canis familiaris	ACTR3	VGNC	VGNC:59392
Rattus norvegicus	ACTR3	RGD	RGD:71024
Mus musculus	ACTR3	MGD	MGI:1921367
Others	ACTR3	NCBI

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