2. Gene
  3. JUND - JunD proto-oncogene, AP-1 transcription factor subunit Gene

JUND - JunD proto-oncogene, AP-1 transcription factor subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AP-1

Gene ID: 3727 | Gene type: protein coding

About JUND

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,279,694-18,281,622 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 2 paralogues.

Summary

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and Apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

JUND Products(2)

mRNA Protein Name
NM_001286968.2 NP_001273897.1 transcription factor JunD isoform deltaJunD
NM_005354.6 NP_005345.3 transcription factor JunD isoform JunD-FL
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9989505 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
1903194 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22327296 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10508860 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
20102225 GOA
part of transcription factor AP-1 complex IDA
IDA: Inferred from direct assay
10508860 GOA
part of transcription repressor complex IPI
IPI: Inferred from physical interaction
22327296 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JUND Protein Structure

Jun

Jun: Jun-like transcription factor (1 - 257)

bZIP_1

bZIP_1: bZIP transcription factor (266 - 328)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
Protein Preferred Names Protein Names

transcription factor JunD

activator protein 1

JUND Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
JUND P17535 BATF3 Homo sapiens Q9NR55
Peptide Array
20102225
Intra
JUND P17535 ATF2 Homo sapiens P15336
Peptide Array
20102225
Intra
JUND P17535 ACTR3 Homo sapiens P61158
Display Tech
20195357
Intra
JUND P17535 FOSL2 Homo sapiens P15408
Peptide Array
20102225
Intra
JUND P17535 MDM2 Homo sapiens Q00987
TAP
20195357
Intra
JUND P17535 ATF3 Homo sapiens P18847
Peptide Array
20102225
Intra
JUND P17535 MAPK10 Homo sapiens P53779
Protein Kinase Assay
22327296
Intra
JUND P17535 MAPK10 Homo sapiens P53779
Pull Down
22327296
Intra
JUND P17535 BATF Homo sapiens Q16520
Peptide Array
20102225
Intra
JUND P17535 ATF7 Homo sapiens P17544
Peptide Array
20102225
Intra
JUND P17535 FOS Homo sapiens P01100
Display Tech
20195357
Intra
JUND P17535 FOS Homo sapiens P01100
TAP
20195357
Intra
JUND P17535 FOS Homo sapiens P01100
Peptide Array
20102225
Intra
JUND P17535 MEN1 Homo sapiens O00255-2
Pull Down
22327296
Cross
JUND P17535 MDV005 Gallid herpesvirus 2 Q9DGW5
Peptide Array
20102225
Cross
JUND P17535 HBZ Human T-cell leukemia virus 1 P0C746
Peptide Array
20102225
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1

MEN1

Wermer Syndrome

Multiple Endocrine Neoplasia 1

Multiple Endocrine Neoplasia, Type 1

Men I

Endocrine Adenomatosis, Multiple

Mea I

Men Type I

Wermer'S Syndrome

Men1 Syndrome

Multiple Endocrine Adenomatosis

Endocrine Adenomatosis Multiple

Men 1

Familial Multiple Endocrine Neoplasia Type I

Neoplasia, Endocrine, Multiple, Type 1

Multiple Endocrine Neoplasia
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia

Atll

Adult T-Cell Leukaemia

Adult T-Cell Leukaemia/Lymphoma

Adult T-Cell Lymphoma

T Cell Leukemia Lymphoma Adult

Leukemia-Lymphoma, Adult T-Cell

Leukemia, T-Cell

Adult T-Cell Lymphoma/Leukemia
T-Cell Adult Acute Lymphocytic Leukemia

Acute Adult T-Cell Leukemia-Lymphoma

Adult Precursor T Lymphoblastic Leukemia

Atll

T-Cell Adult Acute Lymphoblastic Leukemia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07060 JUND Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus JUND RGD RGD:2945
Felis catus JUND VGNC VGNC:102618
Canis familiaris JUND VGNC VGNC:42199
Mus musculus JUND MGD MGI:96648