2. Gene
  3. ACTR1B - actin related protein 1B Gene

ACTR1B - actin related protein 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PC3; ARP1B; CTRN2

Gene ID: 10120 | Gene type: protein coding

About ACTR1B

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:97,655,939-97,664,044 (from NCBI)

This gene has 3 transcripts (splice variants), 112 orthologues and 26 paralogues. Ubiquitous expression in spleen (RPKM 24.2), brain (RPKM 24.1) and 25 other tissues.

Summary

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]

ACTR1B Products(1)

mRNA Protein Name
NM_005735.4 NP_005726.1 beta-centractin
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12857853 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACTR1B Protein Structure

Actin

Actin: Actin (9 - 376)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

beta-centractin

ARP1 actin related protein 1 homolog B

ACTR1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
ACTR1B P42025 Actr10 Mus musculus Q9QZB7
Pull Down
12857853
Intra
ACTR1B P42025 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
ACTR1B P42025 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
ACTR1B P42025 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
ACTR1B P42025 DCTN1 Homo sapiens Q14203
Density Sedimentation
12857853
Cross: Cross-species interaction Intra: Intraspecies interaction

ACTR1B Antibodies

Cat. No. Product Name Application Reactivity
HY-P82941 ACTR1B Antibody (YA2686) WB, IHC-F, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage

Alcoholic Gastritis, Without Mention Of Hemorrhage

Alcohol Gastritis

Etoh Gastritis
Alcoholic Psychosis

Psychoses, Alcoholic

Alcoholic Psychoses
Brachydactyly, Type A3

Brachydactyly Type A3

BDA3

Brachydactyly-Clinodactyly

Brachymesophalangy V

Brachymesophalangy 5

Brachydactyly Clinodactyly
Alcohol-Induced Mental Disorder

Psychoses, Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00229 ACTR1B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACTR1B MGD MGI:1917446
Bos taurus ACTR1B VGNC VGNC:54395
Felis catus ACTR1B VGNC VGNC:59555
Rattus norvegicus ACTR1B RGD RGD:1307380
Canis familiaris ACTR1B VGNC VGNC:37553
Macaca mulatta ACTR1B VGNC VGNC:69435