AKAP9 - A-kinase anchoring protein 9 Gene

Homo sapiens

Also known as LQT11; PRKA9; AKAP-9; CG-NAP; YOTIAO; AKAP350; AKAP450; PPP1R45; HYPERION; MU-RMS-40.16A

Gene ID: 10142 | Gene type: protein coding

About AKAP9

Cytogenetic location: 7q21.2 Genomic coordinates (GRCh38): 7:91,940,862-92,110,673 (from NCBI)

This gene has 32 transcripts (splice variants), 176 orthologues, 1 paralogue and is associated with 101 phenotypes. Ubiquitous expression in colon (RPKM 12.3), small intestine (RPKM 8.8) and 25 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein Phosphatase 1, protein Phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]

AKAP9 Products(3)

mRNA	Protein	Name
NM_001379277.1	NP_001366206.1	A-kinase anchor protein 9 isoform 4
NM_005751.5	NP_005742.4	A-kinase anchor protein 9 isoform 2
NM_147185.3	NP_671714.1	A-kinase anchor protein 9 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	11799244	GOA
enables potassium channel regulator activity	IMP IMP: Inferred from mutant phenotype	16002409	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12163479	GOA
enables protein kinase A regulatory subunit binding	IDA IDA: Inferred from direct assay	21502359	GOA
enables protein kinase A regulatory subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	11799244	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cAMP	IMP IMP: Inferred from mutant phenotype	16002409	GOA
involved in maintenance of centrosome location	IMP IMP: Inferred from mutant phenotype	25657325	GOA
involved in microtubule nucleation	IMP IMP: Inferred from mutant phenotype	19242490	GOA
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	29162697	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18093912	GOA
involved in positive regulation of potassium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16002409	GOA
involved in protein-containing complex localization	IDA IDA: Inferred from direct assay	19218243	GOA
involved in regulation of Golgi organization	IDA IDA: Inferred from direct assay	27666745	GOA
involved in regulation of cardiac muscle cell action potential involved in regulation of contraction	IMP IMP: Inferred from mutant phenotype	18093912	GOA
involved in regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	18093912	GOA
involved in regulation of membrane repolarization	IMP IMP: Inferred from mutant phenotype	16002409	GOA
involved in regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	18093912	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12163479	GOA
located in Golgi stack	IDA IDA: Inferred from direct assay	19242490	GOA
located in centrosome	IDA IDA: Inferred from direct assay	20096683	GOA
located in cis-Golgi network	IDA IDA: Inferred from direct assay	24648492	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10390370	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	10390370	GOA
part of potassium channel complex	IDA IDA: Inferred from direct assay	19218243	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	11799244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP9 Protein Structure

PACT_coil_coil

0
700
1400
2100
2800
3500
3907 a.a.

Protein Preferred Names

Protein Names

A-kinase anchor protein 9

A kinase (PRKA) anchor protein (yotiao) 9

AKAP9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKAP9	Q99996	BIRC6	Homo sapiens	Q9NR09	Anti Tag CoIP	33961781
Cross	AKAP9	Q99996	P0DTD1-PRO_0000449630	SARS-CoV-2	P0DTD1-PRO_0000449630	Y2H Array	36217030
Intra	AKAP9	Q99996	GOLGA2	Homo sapiens	Q08379	Anti Bait CoIP	19242490
Intra	AKAP9	Q99996	KDM1A	Homo sapiens	O60341	Y2H	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Long Qt Syndrome 11

LQT11	Long Qt Syndrome-11
Qt Syndrome, Long, Type 11

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Cardiac Arrhythmia, Ankyrin-B-Related

Long Qt Syndrome 4	Ankyrin-B Syndrome
LQT4	Ankyrin-B-Related Cardiac Arrhythmia
Sick Sinus Syndrome With Bradycardia	Arrhythmia, Cardiac, Ankyrin B-Related

Long Qt Syndrome 12

LQT12

Qt Syndrome, Long, Type 12

Long Qt Syndrome 10

LQT10	Atrial Fibrillation, Familial, 17
ATFB17	Long Qt Syndrome-10
Qt Syndrome, Long, Type 10

Long Qt Syndrome 5

LQT5	Long Qt Syndrome 2/5
Lqt2/5	Susceptibility To Acquired Long Qt Syndrome 5
Long Qt Syndrome-5	Long Qt Syndrome 5, Acquired, Susceptibility To
Qt Syndrome, Long, Type 5	Long Qt Syndrome 2-5

Long Qt Syndrome 9

LQT9	Long Qt Syndrome-9
Qt Syndrome, Long, Type 9

Long Qt Syndrome 13

LQT13

Qt Syndrome, Long, Type 13

Long Qt Syndrome 15

LQT15

Long Qt Syndrome, Type 15

Long Qt Syndrome 2

LQT2	Long Qt Syndrome, Acquired, Reduced Susceptibility To
Long Qt Syndrome 1/2	Long Qt Syndrome 2/3
Long Qt Syndrome 2/5	Long Qt Syndrome 2, Acquired, Susceptibility To
Long Qt Syndrome, Acquired, Reduced	Long Qt Syndrome Type 2
Long Qt Syndrome 2/9	Lqt1/2
Lqt2/3	Lqt2/5
Lqt2/9	Susceptibility To Acquired Long Qt Syndrome 2
Long Qt Syndrome-2	Qt Syndrome, Long, Type 2
Long Qt Syndrome 1-2	Long Qt Syndrome 2-3
Long Qt Syndrome 2-5	Long Qt Syndrome 9

Cardiomyopathy, Familial Hypertrophic, 4

Hypertrophic Cardiomyopathy 4	CMH4
Cardiomyopathy, Hypertrophic, 4	Cardiomyopathy, Familial Hypertrophic 4
Cardiomyopathy, Familial Hypertrophic, 4, Susceptibility To	Cardiomyopathy, Hypertrophic, Familial, Type 4

Long Qt Syndrome 3

LQT3	Long Qt Syndrome Type 3
Long Qt Syndrome-3	Qt Syndrome, Long, Type 3

Microcephaly 1, Primary, Autosomal Recessive

MCPH1	Premature Chromosome Condensation Syndrome
Pcc Syndrome	Primary Autosomal Recessive Microcephaly 1
Microcephaly, Primary Autosomal Recessive, 1	Premature Chromosome Condensation With Microcephaly And Mental Retardation
Microcephaly Vera	True Microcephaly
Microcephaly, Type 1, Primary, Autosomal Recessive	Autosomal Recessive Primary Microcephaly

Andersen Cardiodysrhythmic Periodic Paralysis

Andersen Syndrome	Andersen-Tawil Syndrome
LQT7	Long Qt Syndrome 7
Ats	Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type
Long Qt Syndrome Type 7	Andersen Tawil Syndrome
Potassium-Sensitive Cardiodysrhythmic Type	Lqts Type 7
Long Qt Syndrome-7

Timothy Syndrome

Long Qt Syndrome With Syndactyly	TS
Lqt8	Long Qt Syndrome 8
Long Qt Syndrome Type 8	Long Qt Syndrome-Syndactyly Syndrome

Catecholaminergic Polymorphic Ventricular Tachycardia

Cpvt	Catecholamine-Induced Polymorphic Ventricular Tachycardia
Familial Polymorphic Ventricular Tachycardia	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Stress-Induced Polymorphic Ventricular Tachycardia
Bidirectional Tachycardia Induced By Catecholamine	Double Tachycardia Induced By Catecholamines
Polymorphic Catecholergic Ventricular Tachycardia	Syncopal Paroxysmal Tachycardia
Bidirectional Tachycardia Induced By Catecholamines	Fpvt
Bidirectional Ventricular Tachycardia Induced By Catecholamine	Polymorphic Ventricular Tachycardia Induced By Catecholamines
Ventricular Tachycardia, Catecholaminergic Polymorphic	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Familial Ventricular Tachycardia	Multifocal Pvcs
Multifocal Premature Ventricular Beats

Jervell And Lange-Nielsen Syndrome 1

Jervell And Lange-Nielsen Syndrome	Jervell-Lange Nielsen Syndrome
Prolonged Qt Interval In Ekg And Sudden Death	Cardioauditory Syndrome Of Jervell And Lange-Nielsen
Surdo-Cardiac Syndrome	JLNS1
Deafness, Congenital, And Functional Heart Disease	Jlns
Long Qt Interval-Deafness Syndrome	Jervell And Lange-Nielson Syndrome
Jervell Lange-Nielsen Syndrome	Autosomal Recessive Long Qt Syndrome
Cardio-Auditory-Syncope Syndrome	Long Qt Interval-Hearing Loss Syndrome
Congenital Deafness And Functional Heart Disease	Long Qt Interval-Deafness

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Intrinsic Cardiomyopathy

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00525	AKAP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AKAP9	VGNC	VGNC:59719
Bos taurus	AKAP9	VGNC	VGNC:25791
Macaca mulatta	AKAP9	VGNC	VGNC:69774
Rattus norvegicus	AKAP9	RGD	RGD:620833
Canis familiaris	AKAP9	VGNC	VGNC:37763
Mus musculus	AKAP9	MGD	MGI:2178217

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