EBI3 - Epstein-Barr virus induced 3 Gene

Homo sapiens

Also known as IL27B; IL35B; IL-27B

Gene ID: 10148 | Gene type: protein coding

About EBI3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,229,523-4,237,528 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 23 paralogues. Biased expression in placenta (RPKM 82.3), spleen (RPKM 9.3) and 2 other tissues.

Summary

This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus Infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the JAK/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

EBI3 Products(1)

mRNA	Protein	Name
NM_005755.3	NP_005746.2	interleukin-27 subunit beta precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine receptor activity	IPI IPI: Inferred from physical interaction	9342359	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9342359	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBI3 Protein Structure

fn3

0
100
200
229 a.a.

Protein Preferred Names

Protein Names

interleukin-27 subunit beta

EBV-induced gene 3 protein

Recombinant EBI3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70338	IL-35 Protein, Human (HEK293, Fc)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P73199	IL-27 Protein, Human (CHO, His)	Q14213 (R21-K229)&Q8NEV9 (F29-P243)	≥95%
HY-P73880	IL-35 Protein, Human (HEK293, Flag-His)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P73882	IL-35 Protein, Human (HEK293, His, hFc-Flag)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P700118AF	Animal-Free IL-27 beta/EBI3 Protein, Human (His)	Q14213 (R21-K229)	≥95%

Related Diseases

Diseases

Alias

Sialadenitis

Sialoadenitis	Adenitis, Salivary Gland
Salivary Gland Inflammation	Salivary Gland Adenitis
Sialitis	Inflammation Of Salivary Gland
Inflammation Of Salivary Duct Or Gland	Salivary Glandular Adenitis
Sialoangiitis	Sialoangitis
Sialodochitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04128	EBI3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EBI3	RGD	RGD:1589467
Mus musculus	EBI3	MGD	MGI:1354171

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