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  4. Interleukin & Receptors
  5. IL-27

IL-27

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IL-27 (Interleukin-27) is a heterodimeric cytokine of the IL-12 family, composed of two subunits, EBI3 (Epstein-Barr-virus-induced molecule 3) and p28[1]. IL-27 enhances the development, proliferation, and cytotoxic activity of CD8+ T cells, thereby indirectly promoting anti-tumor immunity. IL-27 shows pro- and anti-inflammatory, suppresses T-cell proliferation, stimulates cytotoxic T-cell activity, induces isotype switching in B-cells, particularly with regards to inhibition of Th2, Th17 and Treg differentiation, and that has diverse effects on innate immune cells[2]. IL-27 activates STAT1, STAT3, STAT6, ERK and p38 MAPKs, and Akt, resulting in enhanced cell proliferation[3]. IL-27 drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR[4].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73199
    IL-27 Protein, Human (CHO, His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Human CHO
    IL-27 (Interleukin-27) is a heterodimeric cytokine of the IL-12 family, composed of two subunits, EBI3 (Epstein-Barr-virus-induced molecule 3) and p28. IL-27 enhances the development, proliferation, and cytotoxic activity of CD8+ T cells, thereby indirectly promoting anti-tumor immunity[ 2]. IL-27 Protein, Human (CHO, His) is a recombinant protein with a His label that consists of two subunits, EBI3 (IL27B) (229 amino acids (M1-K229)) and IL27A (214 amino acids (F29-P243)), is produced by CHO cells.
  • HY-P73200
    IL-27 Protein, Mouse (228a.a, HEK293, His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Mouse HEK293
    IL-27 (Interleukin-27) is a heterodimeric cytokine of the IL-12 family, composed of two subunits, EBI3 (Epstein-Barr-virus-induced molecule 3) and p28. IL-27 enhances the development, proliferation, and cytotoxic activity of CD8+ T cells, thereby indirectly promoting anti-tumor immunity[ 2]. IL-27 Protein, Mouse (228a.a, HEK293, His) is a recombinant protein with a His label that consists of two subunits, EBI3 (IL27B) (228 amino acids (M1-P228)) and IL27A (205 amino acids (F29-S234)), and is produced by HEK293 cells.
  • HY-P700118AF
    Animal-Free IL-27 beta/EBI3 Protein, Human (His)

    Interleukin-27 subunit alpha; IL-27-A; Interleukin-27 subunit beta; IL-27B; Epstein-Barr virus-in_x0002_duced gene 3 protein; EBV-induced gene 3 protein; EBI3; p28; Interleukin-30; IL-30

    		Human E. coli
    The IL-27 beta/EBI3 protein binds to IL27 to form IL-27 interleukin, which is critical in innate immunity. IL-27 has both pro- and anti-inflammatory properties, regulating T helper cell development, inhibiting T cell proliferation, stimulating cytotoxic T cell activity, inducing B cell isotype switching, and affecting innate immune cells. Animal-Free IL-27 beta/EBI3 Protein, Human (His) is the recombinant human-derived animal-FreeIL-27 beta/EBI3 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-27 beta/EBI3 Protein, Human (His) is 209 a.a., with molecular weight of ~24.25 kDa.
  • HY-P700202AF
    Animal-Free IL-27 EBI3 Protein, Mouse (His)

    Interleukin-27 subunit beta; IL-27 subunit beta; IL-27B; Epstein-Barr virus-induced gene 3 protein homolog

    		Mouse E. coli
    The IL-27 protein together with IL23A forms IL-23 interleukin, a key cytokine in innate and adaptive immunity. It is associated with infection responses, binds to IL12RB1 and IL23R receptor complexes, and activates Jak-Stat signaling. Animal-Free IL-27 EBI3 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-27 EBI3 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-27 EBI3 Protein, Mouse (His) is 206 a.a., with molecular weight of ~23.84 kDa.
  • HY-P73200A
    IL-27 Protein, Mouse (228a.a, HEK293, C-His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Mouse HEK293
    IL-27 Proteinas, along with IL23A, forms the IL-23 interleukin, a key cytokine in innate and adaptive immunity. It's implicated in infection response, binding to the IL12RB1 and IL23R receptor complex, activating Jak-Stat signaling. IL-23 stimulates memory T-cells, promoting pro-inflammatory cytokine production. It contributes to autoimmune inflammation and is implicated in tumorigenesis. IL-12, a growth factor for activated T and NK cells, enhances NK cell lytic activity and stimulates interferon-gamma production by resting PBMC. IL-27 Protein, Mouse (228a.a, HEK293, C-His) is a recombinant protein dimer complex containing IL-27 Protein and IL-27A, expressed by HEK293 , with C-10*His labeled tag and GSGSGGSGGSGSGKL peptide. IL-27 Protein, Mouse (228a.a, HEK293, C-His), has molecular weight of ~57.6 kDa.
  • HY-P73200Y
    IL-27 Protein, Mouse (228a.a, HEK293, His, solution)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Mouse HEK293
    The IL-27 protein together with IL23A forms IL-23 interleukin, a key cytokine in innate and adaptive immunity. It is associated with infection responses, binds to IL12RB1 and IL23R receptor complexes, and activates Jak-Stat signaling. IL-27 Protein, Mouse (228a.a, HEK293, His, solution) is the recombinant mouse-derived IL-27, expressed by HEK293 , with C-10*His labeled tag. ,
  • HY-P72554
    IL-27 Protein, Mouse (HEK293, His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Mouse HEK293
    IL-27 (Interleukin-27) is a heterodimeric cytokine of the IL-12 family, composed of two subunits, EBI3 (Epstein-Barr-virus-induced molecule 3) and p28. IL-27 enhances the development, proliferation, and cytotoxic activity of CD8+ T cells, thereby indirectly promoting anti-tumor immunity[ 2]. IL-27 Protein, Mouse (HEK293, His) is a recombinant protein with a His label that consists of two subunits, EBI3 (IL27B) (209 amino acids (Y19-P228)) and IL27A (205 amino acids (F29-S234)), and is produced by HEK293 cells.
  • HY-P700122AF
    Animal-Free IL-30/IL-27A Protein, Human (His)

    Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28

    		Human E. coli
    IL-30/IL-27A proteins cooperate with EBI3 to form IL-27, a key cytokine in innate immunity with pro- and anti-inflammatory properties. IL-27 regulates T helper cell development, inhibits T cell proliferation and affects various immune cells, affects CD4 T helper cell differentiation and promotes rapid clonal expansion. Animal-Free IL-30/IL-27A Protein, Human (His) is the recombinant human-derived animal-FreeIL-30/IL-27A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-30/IL-27A Protein, Human (His) is 215 a.a., with molecular weight of ~25.47 kDa.
  • HY-P700206AF
    Animal-Free IL-30/IL-27A Protein, Mouse (His)

    IL-27 p28 subunit; IL-27 subunit alpha; IL27; IL-27; IL27A; IL-27-A; IL27-A; IL27p28; IL30; interleukin 27; interleukin 30; interleukin-27 subunit alpha; MGC71873; p28IL-27A

    		Mouse E. coli
    The IL-30/IL-27A protein is a component of the Ragulator complex, which is critical for amino acids and activates mTORC1 to regulate cell growth in response to different signals. The lysosomal V-ATPase and Ragulator complex act as GEFs for Rag GTPase, promoting amino acid activation. Animal-Free IL-30/IL-27A Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-30/IL-27A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-30/IL-27A Protein, Mouse (His) is 206 a.a., with molecular weight of ~24.51 kDa.
Cat. No. Product Name Effect Purity