NME6 - NME/NM23 nucleoside diphosphate kinase 6 Gene

Homo sapiens

Also known as NDK 6; NM23-H6; IPIA-ALPHA

Gene ID: 10201 | Gene type: protein coding

About NME6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,288,402-48,301,367 (from NCBI)

This gene has 22 transcripts (splice variants), 182 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 3.8), ovary (RPKM 2.8) and 25 other tissues.

Summary

Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous Enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

NME6 Products(9)

mRNA	Protein	Name
NM_001308426.2	NP_001295355.1	nucleoside diphosphate kinase 6 isoform 2
NM_001308427.2	NP_001295356.1	nucleoside diphosphate kinase 6 isoform 2
NM_001308428.2	NP_001295357.1	nucleoside diphosphate kinase 6 isoform 2
NM_001308430.2	NP_001295359.1	nucleoside diphosphate kinase 6 isoform 3
NM_001308431.2	NP_001295360.1	nucleoside diphosphate kinase 6 isoform 4
NM_001308433.2	NP_001295362.1	nucleoside diphosphate kinase 6 isoform 4
NM_001308434.2	NP_001295363.1	nucleoside diphosphate kinase 6 isoform 5
NM_001308435.2	NP_001295364.1	nucleoside diphosphate kinase 6 isoform 6
NM_005793.5	NP_005784.1	nucleoside diphosphate kinase 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nucleoside diphosphate kinase activity	IDA IDA: Inferred from direct assay	10618642	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	10618642	GOA
involved in negative regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	10618642	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	34789336	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	34789336	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	10618642	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NME6 Protein Structure

NDK

0
100
186 a.a.

Protein Preferred Names

Protein Names

nucleoside diphosphate kinase 6

NDP kinase 6

NME6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NME6	O75414	RCC1L	Homo sapiens	Q96I51	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lymph Node Carcinoma

Lymph Node Cancer	Lymph Node Neoplasm
Neoplasm Of Lymph Node

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09377	NME6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NME6	VGNC	VGNC:32128
Felis catus	NME6	VGNC	VGNC:63836
Macaca mulatta	NME6	VGNC	VGNC:75222
Canis familiaris	NME6	VGNC	VGNC:43857
Rattus norvegicus	NME6	RGD	RGD:61896
Mus musculus	NME6	MGD	MGI:1861676

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