DHRS2 - dehydrogenase/reductase 2 Gene

Homo sapiens

Also known as HEP27; SDR25C1

Gene ID: 10202 | Gene type: protein coding

About DHRS2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,630,115-23,645,639 (from NCBI)

This gene has 10 transcripts (splice variants), 692 orthologues and 13 paralogues. Biased expression in urinary bladder (RPKM 75.6), salivary gland (RPKM 7.2) and 3 other tissues.

Summary

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are Enzymes that metabolize many different compounds, such as steroid Hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

DHRS2 Products(3)

mRNA	Protein	Name
NM_001318835.1	NP_001305764.1	dehydrogenase/reductase SDR family member 2, mitochondrial isoform 3
NM_005794.4	NP_005785.1	dehydrogenase/reductase SDR family member 2, mitochondrial isoform 2
NM_182908.5	NP_878912.1	dehydrogenase/reductase SDR family member 2, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carbonyl reductase (NADPH) activity	IDA IDA: Inferred from direct assay	16685466	GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA IDA: Inferred from direct assay	16685466	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	19443906	GOA
involved in electron transport chain	IDA IDA: Inferred from direct assay	16685466	GOA
involved in myeloid dendritic cell differentiation	IEP IEP: Inferred from expression pattern	11944995	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19443906	GOA
involved in response to toxic substance	IDA IDA: Inferred from direct assay	16685466	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11944995	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	19443906	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	11997086	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1847869	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHRS2 Protein Structure

adh_short_C2

0
100
200
280 a.a.

Protein Preferred Names

Protein Names

dehydrogenase/reductase SDR family member 2, mitochondrial

dehydrogenase/reductase (SDR family) member 2

DHRS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DHRS2	Q13268	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	DHRS2	Q13268	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]

Middle Ear Disease

Middle Ear Anomaly

Disorder Of Middle Ear

Petrositis

Acute Petrositis	Chronic Petrositis
Inflammation Of Petrous Bone	Osteitis Of Petrous Bone
Osteomyelitis Of Petrous Bone

Suppurative Otitis Media

Otitis Media With Effusion - Purulent	Purulent Otitis Media
Otitis Media, Suppurative

Mastoiditis

Mastoiditis Nec

Otorrhea

Discharging Ear

Epiglottitis

Acute Epiglottitis	Acute Epiglottitis And Supraglottitis
Acute Epiglottiditis	Epiglottiditis
Epiglottitis Nos

Ulcerative Blepharitis

Salpingo-Oophoritis

Tubo-Ovarian Inflammatory Disease	Salpingitis/Oophoritis
Suppurative Salpingo Oophoritis	Tubo-Ovarian Inflammation
Tubo-Ovarian Inflammatory Disorder	Purulent Salpingo Oophoritis
Septic Salpingo Oophoritis	Salpingo-Ovaritis
Inflammation Oviduct	Ruptured Salpingo Oophoritis
Pyosalpinx Rupture

Auditory System Disease

Ear Diseases

Ear And Mastoid Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110100	CPYPP	Inhibitor	99.94%	Unkown
HY-124711	TBOPP	Inhibitor	99.96%	Unkown
HY-153128	DOCK2-IN-1	Inhibitor	96.20%	Unkown
HY-RS03740	DHRS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DHRS2	VGNC	VGNC:84332
Canis familiaris	DHRS2	VGNC	VGNC:39933
Felis catus	DHRS2	VGNC	VGNC:80988
Rattus norvegicus	DHRS2	RGD	RGD:1583909
Mus musculus	DHRS2	MGD	MGI:1918662

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