TRIM13 - tripartite motif containing 13 Gene

Homo sapiens

Also known as CAR; LEU5; RFP2; DLEU5; RNF77

Gene ID: 10206 | Gene type: protein coding

About TRIM13

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,997,042-50,018,467 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 80 paralogues. Broad expression in testis (RPKM 17.7), bone marrow (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

TRIM13 Products(4)

mRNA	Protein	Name
NM_001007278.3	NP_001007279.1	E3 ubiquitin-protein ligase TRIM13 isoform 2
NM_005798.5	NP_005789.2	E3 ubiquitin-protein ligase TRIM13 isoform 1
NM_052811.4	NP_434698.1	E3 ubiquitin-protein ligase TRIM13 isoform 1
NM_213590.3	NP_998755.1	E3 ubiquitin-protein ligase TRIM13 isoform 1

TRIM13 Protein Structure

zf-RING_2

zf-B_box

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM13

B-cell chronic lymphocytic leukemia tumor suppressor Leu5

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Adrenal Gland Pheochromocytoma

Pheochromocytoma

Pain Agnosia

Analgesia

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Late-Onset Retinal Degeneration

LORD	Retinal Degeneration, Late-Onset, Autosomal Dominant
Autosomal Dominant Late-Onset Retinal Degeneration	Pigmentary Retinopathy
Retinal Degeneration, Late-Onset	Retinitis Pigmentosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15021	TRIM13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRIM13	VGNC	VGNC:47805
Rattus norvegicus	TRIM13	RGD	RGD:1307609
Felis catus	TRIM13	VGNC	VGNC:69301
Bos taurus	TRIM13	VGNC	VGNC:36314
Mus musculus	TRIM13	MGD	MGI:1913847
Macaca mulatta	TRIM13	VGNC	VGNC:79972

Name
Email *

	Sorry, but the email address you supplied was invalid.