USPL1 - ubiquitin specific peptidase like 1 Gene

Homo sapiens

Also known as C13orf22; D13S106E; bA121O19.1

Gene ID: 10208 | Gene type: protein coding

About USPL1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:30,617,920-30,660,766 (from NCBI)

This gene has 3 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 10.5), bone marrow (RPKM 8.9) and 25 other tissues.

Summary

Enables SUMO binding activity and SUMO-specific isopeptidase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by Alliance of Genome Resources, Apr 2022]

USPL1 Products(4)

mRNA	Protein	Name
NM_001321532.2	NP_001308461.1	SUMO-specific isopeptidase USPL1 isoform 2
NM_001321533.2	NP_001308462.1	SUMO-specific isopeptidase USPL1 isoform 3
NM_001321534.2	NP_001308463.1	SUMO-specific isopeptidase USPL1 isoform 3
NM_005800.5	NP_005791.3	SUMO-specific isopeptidase USPL1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO binding	IDA IDA: Inferred from direct assay	22878415	GOA
enables deSUMOylase activity	IDA IDA: Inferred from direct assay	22878415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
NOT enables ubiquitin binding	IDA IDA: Inferred from direct assay	22878415	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Cajal body organization	IMP IMP: Inferred from mutant phenotype	22878415	GOA
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	22878415	GOA
involved in protein desumoylation	IDA IDA: Inferred from direct assay	22878415	GOA
involved in snRNA transcription	IMP IMP: Inferred from mutant phenotype	24413172	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	22878415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USPL1 Protein Structure

Peptidase_C98

DUF4650

0
200
400
600
800
1000
1092 a.a.

Protein Preferred Names

Protein Names

SUMO-specific isopeptidase USPL1

USP-like 1

USPL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USPL1	Q5W0Q7	SUMO3	Homo sapiens	P55854	Validated Y2H	25416956
Intra	USPL1	Q5W0Q7	SUMO3	Homo sapiens	P55854	Enzymatic Study	22878415
Intra	USPL1	Q5W0Q7	SUMO3	Homo sapiens	P55854	Y2H Array	25416956
Intra	USPL1	Q5W0Q7	SUMO3	Homo sapiens	P55854	Y2H Prey Pooling	25416956
Intra	USPL1	Q5W0Q7	SUMO3	Homo sapiens	P55854	Pull Down	22878415
Intra	USPL1	Q5W0Q7	SUMO1	Homo sapiens	P63165	Pull Down	22878415
Intra	USPL1	Q5W0Q7	SUMO1	Homo sapiens	P63165	Enzymatic Study	22878415

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chronic Follicular Conjunctivitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15572	USPL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	USPL1	MGD	MGI:2442342
Bos taurus	USPL1	VGNC	VGNC:36740
Canis familiaris	USPL1	VGNC	VGNC:48206
Macaca mulatta	USPL1	VGNC	VGNC:79240
Felis catus	USPL1	VGNC	VGNC:66899
Rattus norvegicus	USPL1	RGD	RGD:1310835

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