TRIB1 - tribbles pseudokinase 1 Gene

Homo sapiens

Also known as C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1

Gene ID: 10221 | Gene type: protein coding

About TRIB1

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:125,430,358-125,438,403 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 87.7), liver (RPKM 53.0) and 20 other tissues.

Summary

Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRIB1 Products(2)

mRNA	Protein	Name
NM_001282985.2	NP_001269914.1	tribbles homolog 1 isoform 2
NM_025195.4	NP_079471.1	tribbles homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17724128	GOA
enables mitogen-activated protein kinase kinase binding	IDA IDA: Inferred from direct assay	15299019	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25852190	GOA
enables protein kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	15299019	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	17452330	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	15299019	GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17452330	GOA
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	15299019	GOA
involved in negative regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	17452330	GOA
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17452330	GOA
involved in regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	15299019	GOA
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17452330	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17452330	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17452330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIB1 Protein Structure

Pkinase

0
100
200
300
372 a.a.

Protein Preferred Names

Protein Names

tribbles homolog 1

G-protein-coupled receptor induced protein

Related Diseases

Diseases

Alias

Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia	Familial Hypobetalipoproteinemia 1
Familial Hypobetalipoproteinemia	FHBL1
Hypobetalipoproteinemia, Familial	Fhbl
Acanthocytosis With Hypobetalipoproteinemia	Hypobetalipoproteinemias
Hypobetalipoproteinemia, Normotriglyceridemic	Hypo-Beta-Lipoproteinemia
Hypobetalipoprotéinemia, Familial	Normotriglyceridemic Hypobetalipoproteinemia
Hypobetalipoproteinemia, Familial, Type 1

Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V	Hyperchylomicronemia, Late-Onset
Familial Type 5 Hyperlipoproteinemia	Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial
Hyperlipidemia, Type V	Hyperlipemia, Mixed
Hyperlipemia, Combined Fat And Carbohydrate-Induced	Familial Hyperlipoproteinemia Type V
Fredrickson Type V Lipaemia	Hyperlipoproteinemia Type 5
Hyperchylomicronemia Late Onset	Hyperlipemia Combined Fat And Carbohydrate-Induced
Hyperlipemia Mixed	Hyperlipidemia Type V
Mixed Hyperlipemia	Type V Hyperlipoproteinemia
Hyperlipoproteinemia 5	HLPP5
Hyperlipidemia, Familial Combined	Mixed Hyperlipidemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15015	TRIB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIB1	MGD	MGI:2443397
Rattus norvegicus	TRIB1	RGD	RGD:621596
Bos taurus	TRIB1	VGNC	VGNC:36308
Macaca mulatta	TRIB1	VGNC	VGNC:79056
Felis catus	TRIB1	VGNC	VGNC:66527
Canis familiaris	TRIB1	VGNC	VGNC:55007
Others	TRIB1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.