2. Gene
  3. MRPS31 - mitochondrial ribosomal protein S31 Gene

MRPS31 - mitochondrial ribosomal protein S31 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as S31mt; IMOGN38; MRP-S31

Gene ID: 10240 | Gene type: protein coding

About MRPS31

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:40,729,128-40,771,190 (from NCBI)

This gene has 4 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in lymph node (RPKM 11.9), testis (RPKM 11.7) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]

MRPS31 Products(1)

mRNA Protein Name
NM_005830.4 NP_005821.2 28S ribosomal protein S31, mitochondrial
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11984006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPS31 Protein Structure

MRP-S31

MRP-S31: Mitochondrial 28S ribosomal protein S31 (96 - 389)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

28S ribosomal protein S31, mitochondrial

imogen 38

MRPS31 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MRPS31 Q92665 STAT3 Homo sapiens P40763
Pull Down
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08685 MRPS31 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MRPS31 VGNC VGNC:63623
Bos taurus MRPS31 VGNC VGNC:31670
Mus musculus MRPS31 MGD MGI:1913153
Canis familiaris MRPS31 VGNC VGNC:43421
Rattus norvegicus MRPS31 RGD RGD:1307668
Macaca mulatta MRPS31 VGNC VGNC:74777