RAMP1 - receptor activity modifying protein 1 Gene

Homo sapiens

Gene ID: 10267 | Gene type: protein coding

About RAMP1

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,858,880-237,912,106 (from NCBI)

This gene has 4 transcripts (splice variants), 250 orthologues and 2 paralogues. Biased expression in endometrium (RPKM 26.3), prostate (RPKM 10.7) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (Calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an Adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP Receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP Receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

RAMP1 Products(2)

mRNA	Protein	Name
NM_001308353.2	NP_001295282.1	receptor activity-modifying protein 1 isoform 2
NM_005855.4	NP_005846.1	receptor activity-modifying protein 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amylin receptor activity	IPI IPI: Inferred from physical interaction	14722252	GOA
enables calcitonin gene-related peptide binding	IPI IPI: Inferred from physical interaction	9620797	GOA
enables calcitonin gene-related peptide receptor activity	IPI IPI: Inferred from physical interaction	9620797	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9620797	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	14722252	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IPI IPI: Inferred from physical interaction	9620797	GOA
involved in amylin receptor signaling pathway	IDA IDA: Inferred from direct assay	14722252	GOA
involved in angiogenesis	IDA IDA: Inferred from direct assay	20596610	GOA
involved in calcitonin gene-related peptide receptor signaling pathway	IPI IPI: Inferred from physical interaction	9620797	GOA
involved in calcium ion transport	IDA IDA: Inferred from direct assay	10882736	GOA
involved in positive regulation of protein glycosylation	IDA IDA: Inferred from direct assay	9620797	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	10882736	GOA
involved in protein transport	IDA IDA: Inferred from direct assay	10882736	GOA
involved in receptor internalization	IDA IDA: Inferred from direct assay	10882736	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CGRP receptor complex	IDA IDA: Inferred from direct assay	9620797	GOA
located in cell surface	IDA IDA: Inferred from direct assay	14722252	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	9620797	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18039931	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	15613468	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAMP1 Protein Structure

RAMP

0
100
148 a.a.

Protein Preferred Names

Protein Names

receptor activity-modifying protein 1

CRLR activity-modifying protein 1

RAMP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAMP1	O60894	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	RAMP1	O60894	NKG7	Homo sapiens	Q16617	Validated Y2H	32296183
Intra	RAMP1	O60894	MAL	Homo sapiens	P21145	Validated Y2H	32296183
Intra	RAMP1	O60894	CALCRL	Homo sapiens	Q16602	3D-EM-Single	33602864

Cross: Cross-species interaction Intra: Intraspecies interaction

RAMP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82073	RAMP1 Antibody (YA1818)	WB	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Cartilage Cancer

Chondrogenic Neoplasm

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes	Reflex Sympathetic Dystrophy
Crps

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1548A	β-CGRP, human TFA		99.17%	Unkown
HY-P1548	β-CGRP, human		98.17%	Unkown
HY-P1548B	β-CGRP, human acetate		/	Unkown
HY-RS11638	RAMP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAMP1	VGNC	VGNC:104553
Mus musculus	RAMP1	MGD	MGI:1858418
Canis familiaris	RAMP1	VGNC	VGNC:59090
Bos taurus	RAMP1	VGNC	VGNC:55666
Felis catus	RAMP1	VGNC	VGNC:69230
Rattus norvegicus	RAMP1	RGD	RGD:61870

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