NKG7 - natural killer cell granule protein 7 Gene

Homo sapiens

Also known as GIG1; GMP-17; p15-TIA-1

Gene ID: 4818 | Gene type: protein coding

About NKG7

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,371,620-51,372,654 (from NCBI)

This gene has 5 transcripts (splice variants), 102 orthologues and 10 paralogues. Biased expression in bone marrow (RPKM 170.3), spleen (RPKM 54.6) and 5 other tissues.

Summary

Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NKG7 Products(2)

mRNA	Protein	Name
NM_001363693.2	NP_001350622.1	protein NKG7 isoform 2
NM_005601.4	NP_005592.1	protein NKG7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to protozoan	IDA IDA: Inferred from direct assay	32839608	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytolytic granule membrane	IDA IDA: Inferred from direct assay	8570616	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8570616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKG7 Protein Structure

PMP22_Claudin

0
100
165 a.a.

Protein Preferred Names

Protein Names

protein NKG7

G-CSF-induced gene 1 protein

Related Diseases

Diseases

Alias

Visceral Leishmaniasis

Kala-Azar	Leishmaniasis, Visceral
Infection By Visceral Leishmaniasis	Leishmaniasis Visceral
Sahib Disease	Ponos
Burdwan Fever	Mard El Bicha
Sirkari Disease	Indian Visceral Leishmaniasis
Dumdum Fever	Visceral Leishmaniasis Due To Leishmania Donovani

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09319	NKG7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NKG7	VGNC	VGNC:68498
Bos taurus	NKG7	VGNC	VGNC:32094
Mus musculus	NKG7	MGD	MGI:1931250
Macaca mulatta	NKG7	VGNC	VGNC:75352
Rattus norvegicus	NKG7	RGD	RGD:621523

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