NKG7 - natural killer cell granule protein 7 Gene

Homo sapiens

Also known as GIG1; GMP-17; p15-TIA-1

Gene ID: 4818 | Gene type: protein coding

About NKG7

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,371,620-51,372,654 (from NCBI)

This gene has 5 transcripts (splice variants), 102 orthologues and 10 paralogues. Biased expression in bone marrow (RPKM 170.3), spleen (RPKM 54.6) and 5 other tissues.

Summary

Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NKG7 Products(2)

mRNA	Protein	Name
NM_001363693.2	NP_001350622.1	protein NKG7 isoform 2
NM_005601.4	NP_005592.1	protein NKG7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to protozoan	IDA IDA: Inferred from direct assay	32839608	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytolytic granule membrane	IDA IDA: Inferred from direct assay	8570616	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8570616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKG7 Protein Structure

PMP22_Claudin

0
100
165 a.a.

Protein Preferred Names

Protein Names

protein NKG7

G-CSF-induced gene 1 protein

NKG7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NKG7	Q16617	SLC30A8	Homo sapiens	Q8IWU4	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	NKG7	Q16617	SLC30A8	Homo sapiens	Q8IWU4	Y2H Array	32296183
Intra	NKG7	Q16617	CLSTN3	Homo sapiens	Q9BQT9	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	CLSTN3	Homo sapiens	Q9BQT9	Validated Y2H	32296183
Intra	NKG7	Q16617	CLSTN3	Homo sapiens	Q9BQT9	Y2H Array	32296183
Intra	NKG7	Q16617	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	NKG7	Q16617	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	NKG7	Q16617	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	NKG7	Q16617	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	NKG7	Q16617	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	NKG7	Q16617	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	NKG7	Q16617	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	NKG7	Q16617	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	NKG7	Q16617	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	NKG7	Q16617	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	NKG7	Q16617	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	NKG7	Q16617	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	NKG7	Q16617	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	NKG7	Q16617	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	ISLR2	Homo sapiens	Q6UXK2	Validated Y2H	32296183
Intra	NKG7	Q16617	ISLR2	Homo sapiens	Q6UXK2	Y2H Array	32296183
Intra	NKG7	Q16617	ISLR2	Homo sapiens	Q6UXK2	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	NKG7	Q16617	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	NKG7	Q16617	CLEC4E	Homo sapiens	Q9ULY5	Validated Y2H	32296183
Intra	NKG7	Q16617	CLEC4E	Homo sapiens	Q9ULY5	Y2H Array	32296183
Intra	NKG7	Q16617	CLEC4E	Homo sapiens	Q9ULY5	Complementation	32296183
Intra	NKG7	Q16617	CLEC4E	Homo sapiens	Q9ULY5	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	NKG7	Q16617	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	NKG7	Q16617	RNF24	Homo sapiens	Q9Y225-2	Y2H Array	32296183
Intra	NKG7	Q16617	RNF24	Homo sapiens	Q9Y225-2	Validated Y2H	32296183
Intra	NKG7	Q16617	RNF24	Homo sapiens	Q9Y225-2	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	NKG7	Q16617	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TMEM88	Homo sapiens	Q6PEY1	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TMEM88	Homo sapiens	Q6PEY1	Validated Y2H	32296183
Intra	NKG7	Q16617	TMEM88	Homo sapiens	Q6PEY1	Y2H Array	32296183
Intra	NKG7	Q16617	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	NKG7	Q16617	MSR1	Homo sapiens	P21757	Y2H Array	31515488
Intra	NKG7	Q16617	MSR1	Homo sapiens	P21757	Y2H Array	25416956
Intra	NKG7	Q16617	MSR1	Homo sapiens	P21757	Y2H Array	32296183
Intra	NKG7	Q16617	MSR1	Homo sapiens	P21757	Y2H Prey Pooling	25416956
Intra	NKG7	Q16617	MSR1	Homo sapiens	P21757	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	SLC18A2	Homo sapiens	Q05940	Y2H Array	32296183
Intra	NKG7	Q16617	SLC18A2	Homo sapiens	Q05940	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	NKG7	Q16617	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	NKG7	Q16617	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	NKG7	Q16617	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	NKG7	Q16617	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TMEM130	Homo sapiens	Q8N3G9	Validated Y2H	32296183
Intra	NKG7	Q16617	TMEM130	Homo sapiens	Q8N3G9	Y2H Array	32296183
Intra	NKG7	Q16617	TMEM130	Homo sapiens	Q8N3G9	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	ATP6AP2	Homo sapiens	O75787	Y2H Array	32296183
Intra	NKG7	Q16617	ATP6AP2	Homo sapiens	O75787	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	NKG7	Q16617	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	NKG7	Q16617	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	NKG7	Q16617	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	NKG7	Q16617	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	NKG7	Q16617	MFSD6	Homo sapiens	Q6ZSS7	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	MFSD6	Homo sapiens	Q6ZSS7	Validated Y2H	32296183
Intra	NKG7	Q16617	MFSD6	Homo sapiens	Q6ZSS7	Y2H Array	32296183
Intra	NKG7	Q16617	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	NKG7	Q16617	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	EDA2R	Homo sapiens	Q9HAV5	Y2H Array	32296183
Intra	NKG7	Q16617	EDA2R	Homo sapiens	Q9HAV5	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	EDA2R	Homo sapiens	Q9HAV5	Validated Y2H	32296183
Intra	NKG7	Q16617	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	NKG7	Q16617	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	NKG7	Q16617	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	NKG7	Q16617	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	NKG7	Q16617	STX1A	Homo sapiens	Q16623	Complementation	32296183
Intra	NKG7	Q16617	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	NKG7	Q16617	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	NKG7	Q16617	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	NKG7	Q16617	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	NKG7	Q16617	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956
Intra	NKG7	Q16617	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	NKG7	Q16617	BAMBI	Homo sapiens	Q13145	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	BAMBI	Homo sapiens	Q13145	Y2H Array	32296183
Intra	NKG7	Q16617	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	NKG7	Q16617	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	NKG7	Q16617	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	NKG7	Q16617	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	NKG7	Q16617	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	NKG7	Q16617	OPRK1	Homo sapiens	P41145	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	OPRK1	Homo sapiens	P41145	Y2H Array	32296183
Intra	NKG7	Q16617	RAMP1	Homo sapiens	O60894	Y2H Prey Pooling	32296183
Intra	NKG7	Q16617	RAMP1	Homo sapiens	O60894	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Visceral Leishmaniasis

Kala-Azar	Leishmaniasis, Visceral
Infection By Visceral Leishmaniasis	Leishmaniasis Visceral
Sahib Disease	Ponos
Burdwan Fever	Mard El Bicha
Sirkari Disease	Indian Visceral Leishmaniasis
Dumdum Fever	Visceral Leishmaniasis Due To Leishmania Donovani

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09319	NKG7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NKG7	VGNC	VGNC:68498
Bos taurus	NKG7	VGNC	VGNC:32094
Mus musculus	NKG7	MGD	MGI:1931250
Macaca mulatta	NKG7	VGNC	VGNC:75352
Rattus norvegicus	NKG7	RGD	RGD:621523

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