2. Gene
  3. NKG7 - natural killer cell granule protein 7 Gene

NKG7 - natural killer cell granule protein 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GIG1; GMP-17; p15-TIA-1

Gene ID: 4818 | Gene type: protein coding

About NKG7

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,371,620-51,372,654 (from NCBI)

This gene has 5 transcripts (splice variants), 102 orthologues and 10 paralogues. Biased expression in bone marrow (RPKM 170.3), spleen (RPKM 54.6) and 5 other tissues.

Summary

Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NKG7 Products(2)

mRNA Protein Name
NM_001363693.2 NP_001350622.1 protein NKG7 isoform 2
NM_005601.4 NP_005592.1 protein NKG7 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in defense response to protozoan IDA
IDA: Inferred from direct assay
32839608 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytolytic granule membrane IDA
IDA: Inferred from direct assay
8570616 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8570616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKG7 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (14 - 149)

  • 0
  • 100
  • 165 a.a.
Protein Preferred Names Protein Names

protein NKG7

G-CSF-induced gene 1 protein

NKG7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NKG7 Q16617 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 SLC30A8 Homo sapiens Q8IWU4
Validated Y2H
32296183
Intra
NKG7 Q16617 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
Intra
NKG7 Q16617 CLSTN3 Homo sapiens Q9BQT9
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 CLSTN3 Homo sapiens Q9BQT9
Validated Y2H
32296183
Intra
NKG7 Q16617 CLSTN3 Homo sapiens Q9BQT9
Y2H Array
32296183
Intra
NKG7 Q16617 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
NKG7 Q16617 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
NKG7 Q16617 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Intra
NKG7 Q16617 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
NKG7 Q16617 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
NKG7 Q16617 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
NKG7 Q16617 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
NKG7 Q16617 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
NKG7 Q16617 CLEC2D Homo sapiens Q9UHP7-3
Validated Y2H
32296183
Intra
NKG7 Q16617 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
Intra
NKG7 Q16617 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
NKG7 Q16617 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
NKG7 Q16617 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
NKG7 Q16617 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 ISLR2 Homo sapiens Q6UXK2
Validated Y2H
32296183
Intra
NKG7 Q16617 ISLR2 Homo sapiens Q6UXK2
Y2H Array
32296183
Intra
NKG7 Q16617 ISLR2 Homo sapiens Q6UXK2
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 MS4A3 Homo sapiens Q96HJ5
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 MS4A3 Homo sapiens Q96HJ5
Validated Y2H
32296183
Intra
NKG7 Q16617 MS4A3 Homo sapiens Q96HJ5
Y2H Array
32296183
Intra
NKG7 Q16617 CLEC4E Homo sapiens Q9ULY5
Validated Y2H
32296183
Intra
NKG7 Q16617 CLEC4E Homo sapiens Q9ULY5
Y2H Array
32296183
Intra
NKG7 Q16617 CLEC4E Homo sapiens Q9ULY5
Complementation
32296183
Intra
NKG7 Q16617 CLEC4E Homo sapiens Q9ULY5
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
NKG7 Q16617 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
NKG7 Q16617 RNF24 Homo sapiens Q9Y225-2
Y2H Array
32296183
Intra
NKG7 Q16617 RNF24 Homo sapiens Q9Y225-2
Validated Y2H
32296183
Intra
NKG7 Q16617 RNF24 Homo sapiens Q9Y225-2
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
NKG7 Q16617 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TMEM88 Homo sapiens Q6PEY1
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TMEM88 Homo sapiens Q6PEY1
Validated Y2H
32296183
Intra
NKG7 Q16617 TMEM88 Homo sapiens Q6PEY1
Y2H Array
32296183
Intra
NKG7 Q16617 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
NKG7 Q16617 MSR1 Homo sapiens P21757
Y2H Array
31515488
Intra
NKG7 Q16617 MSR1 Homo sapiens P21757
Y2H Array
25416956
Intra
NKG7 Q16617 MSR1 Homo sapiens P21757
Y2H Array
32296183
Intra
NKG7 Q16617 MSR1 Homo sapiens P21757
Y2H Prey Pooling
25416956
Intra
NKG7 Q16617 MSR1 Homo sapiens P21757
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 SLC18A2 Homo sapiens Q05940
Y2H Array
32296183
Intra
NKG7 Q16617 SLC18A2 Homo sapiens Q05940
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
NKG7 Q16617 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
NKG7 Q16617 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra
NKG7 Q16617 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
NKG7 Q16617 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TMEM130 Homo sapiens Q8N3G9
Validated Y2H
32296183
Intra
NKG7 Q16617 TMEM130 Homo sapiens Q8N3G9
Y2H Array
32296183
Intra
NKG7 Q16617 TMEM130 Homo sapiens Q8N3G9
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 ATP6AP2 Homo sapiens O75787
Y2H Array
32296183
Intra
NKG7 Q16617 ATP6AP2 Homo sapiens O75787
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
NKG7 Q16617 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
NKG7 Q16617 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra
NKG7 Q16617 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
NKG7 Q16617 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
NKG7 Q16617 MFSD6 Homo sapiens Q6ZSS7
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 MFSD6 Homo sapiens Q6ZSS7
Validated Y2H
32296183
Intra
NKG7 Q16617 MFSD6 Homo sapiens Q6ZSS7
Y2H Array
32296183
Intra
NKG7 Q16617 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
NKG7 Q16617 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 EDA2R Homo sapiens Q9HAV5
Y2H Array
32296183
Intra
NKG7 Q16617 EDA2R Homo sapiens Q9HAV5
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 EDA2R Homo sapiens Q9HAV5
Validated Y2H
32296183
Intra
NKG7 Q16617 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
NKG7 Q16617 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
NKG7 Q16617 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
NKG7 Q16617 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
NKG7 Q16617 STX1A Homo sapiens Q16623
Complementation
32296183
Intra
NKG7 Q16617 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra
NKG7 Q16617 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra
NKG7 Q16617 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
NKG7 Q16617 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
NKG7 Q16617 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Intra
NKG7 Q16617 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Intra
NKG7 Q16617 BAMBI Homo sapiens Q13145
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 BAMBI Homo sapiens Q13145
Y2H Array
32296183
Intra
NKG7 Q16617 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra
NKG7 Q16617 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
NKG7 Q16617 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
NKG7 Q16617 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
NKG7 Q16617 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Intra
NKG7 Q16617 OPRK1 Homo sapiens P41145
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 OPRK1 Homo sapiens P41145
Y2H Array
32296183
Intra
NKG7 Q16617 RAMP1 Homo sapiens O60894
Y2H Prey Pooling
32296183
Intra
NKG7 Q16617 RAMP1 Homo sapiens O60894
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Visceral Leishmaniasis

Kala-Azar

Leishmaniasis, Visceral

Infection By Visceral Leishmaniasis

Leishmaniasis Visceral

Sahib Disease

Ponos

Burdwan Fever

Mard El Bicha

Sirkari Disease

Indian Visceral Leishmaniasis

Dumdum Fever

Visceral Leishmaniasis Due To Leishmania Donovani
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09319 NKG7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NKG7 VGNC VGNC:68498
Bos taurus NKG7 VGNC VGNC:32094
Mus musculus NKG7 MGD MGI:1931250
Macaca mulatta NKG7 VGNC VGNC:75352
Rattus norvegicus NKG7 RGD RGD:621523