EIF1B - eukaryotic translation initiation factor 1B Gene

Homo sapiens

Also known as GC20

Gene ID: 10289 | Gene type: protein coding

About EIF1B

This gene has 4 transcripts (splice variants), 158 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 113.1), bone marrow (RPKM 72.6) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF1B Products(1)

mRNA	Protein	Name
NM_005875.3	NP_005866.1	eukaryotic translation initiation factor 1b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF1B Protein Structure

SUI1

0
100
113 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 1b

protein translation factor SUI1 homolog GC20

EIF1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF1B	O60739	FUS	Homo sapiens	P35637	Y2H Pooling	32814053
Intra	EIF1B	O60739	FUS	Homo sapiens	P35637	Anti Bait CoIP	17353931
Intra	EIF1B	O60739	FUS	Homo sapiens	P35637	Validated Y2H	32814053
Intra	EIF1B	O60739	FUS	Homo sapiens	P35637	Y2H Array	32814053
Intra	EIF1B	O60739	UCHL1	Homo sapiens	P09936	Anti Bait CoIP	17353931
Intra	EIF1B	O60739	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	EIF1B	O60739	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	EIF1B	O60739	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	EIF1B	O60739	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
Intra	EIF1B	O60739	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	EIF1B	O60739	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70207	EIF1B Protein, Human (His)	O60739 (M1-F113)	≥95%

Related Diseases

Diseases

Alias

Mixed Cell Uveal Melanoma

Intraocular Mixed Cell Type Melanoma

Mixed Cell Type Uveal Melanoma

Posterior Uveal Melanoma

Medium/Large Size Posterior Uveal Melanoma	Small Size Posterior Uveal Melanoma
Ciliary Body And Choroid Melanoma, Medium/Large Size	Ciliary Body And Choroid Melanoma, Small Size

Choroid Cancer

Choroid Neoplasm	Choroidal Tumor
Malignant Tumor Of Choroid	Malignant Tumor Of The Choroid
Neoplasm Of Choroid	Choroid Neoplasms
Primary Malignant Neoplasm Of Choroid

Transposition Of The Great Arteries, Dextro-Looped

Transposition Of The Great Arteries	DTGA1
Dextro-Looped Transposition Of The Great Arteries	DTGA
Congenitally Uncorrected Transposition Of The Great Arteries	Congenitally Uncorrected Transposition Of The Great Vessels
D-Tga	Isolated Ventriculoarterial Discordance
Ventriculoarterial Discordance With Atrioventricular Concordance	Dextro-Transposition Of The Great Arteries
Transposition Of The Great Vessels	Great Vessels Transposition
Transposition Of The Great Arteries, Dextro-Looped 1	Arteries, Great, Transposition, Dextro-Looped
Ventriculoarterial Discordance, Isolated	D-Transposition Of The Great Arteries
Complete Transposition	Tga
Tgv	Transposition Of Great Vessels
Transposition Of The Great Arteries Dextro-Looped 1	Dextro-Looped Transposition Of The Great Arteries 1
Discordant Ventriculoarterial Connection	Complete Transposition Of Great Vessels
Great Vessels Complete Transposition	Total Great Vessel Transposition
Transposition Of Great Arteries	Complete Tga - [Transposition Of The Great Arteries]
Tga - [Transposition Of Great Arteries]	Tgv - [Transposition Of Great Vessels]
Transposition Of Great Vessels Nos	Transposed Vessels Nos

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04240	EIF1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EIF1B	VGNC	VGNC:28378
Felis catus	EIF1B	VGNC	VGNC:61768
Mus musculus	EIF1B	MGD	MGI:1916219
Rattus norvegicus	EIF1B	RGD	RGD:1309241
Macaca mulatta	EIF1B	VGNC	VGNC:110369
Others	EIF1B	NCBI

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