CLEC4M - C-type lectin domain family 4 member M Gene

Homo sapiens

Also known as CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR

Gene ID: 10332 | Gene type: protein coding

About CLEC4M

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,763,243-7,769,605 (from NCBI)

This gene has 7 transcripts (splice variants), 924 orthologues and 14 paralogues. Biased expression in liver (RPKM 15.4), lymph node (RPKM 9.8) and 3 other tissues.

Summary

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS Infection. [provided by RefSeq, May 2020]

CLEC4M Products(9)

mRNA	Protein	Name
NM_001144904.2	NP_001138376.1	C-type lectin domain family 4 member M isoform 2
NM_001144905.2	NP_001138377.1	C-type lectin domain family 4 member M isoform 12
NM_001144906.2	NP_001138378.1	C-type lectin domain family 4 member M isoform 7
NM_001144907.2	NP_001138379.1	C-type lectin domain family 4 member M isoform 11
NM_001144908.2	NP_001138380.1	C-type lectin domain family 4 member M isoform 10
NM_001144909.2	NP_001138381.1	C-type lectin domain family 4 member M isoform 9
NM_001144910.2	NP_001138382.1	C-type lectin domain family 4 member M isoform 8
NM_001144911.2	NP_001138383.1	C-type lectin domain family 4 member M isoform 3
NM_014257.5	NP_055072.3	C-type lectin domain family 4 member M isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	12609975	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	15496474	GOA
enables virus receptor activity	IMP IMP: Inferred from mutant phenotype	15496474	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in receptor-mediated virion attachment to host cell	IDA IDA: Inferred from direct assay	15479853	GOA
involved in symbiont entry into host cell	IDA IDA: Inferred from direct assay	15479853	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC4M Protein Structure

Lectin_C

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 4 member M

CD209 antigen-like protein 1

CLEC4M Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	CLEC4M	Q9H2X3	S	SARS-CoV-2	P0DTC2	Anti Tag CoIP	34341769
Intra	CLEC4M	Q9H2X3	GRN	Homo sapiens	P28799	Anti Tag CoIP	33961781
Intra	CLEC4M	Q9H2X3	ACE2	Homo sapiens	Q9BYF1	Pull Down	34341769
Intra	CLEC4M	Q9H2X3	ACE2	Homo sapiens	Q9BYF1	Anti Tag CoIP	34341769
Intra	CLEC4M	Q9H2X3	ACE2	Homo sapiens	Q9BYF1	Anti Bait CoIP	34341769
Intra	CLEC4M	Q9H2X3	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183
Intra	CLEC4M	Q9H2X3	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC4M Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72739	CD299 Protein, Human (HEK293, His-Flag)	Q9H2X3-8 (S73-E376)	≥95%
HY-P76218	CD299 Protein, Human (HEK293)	Q9H2X3 (Q71-E399)	≥95%
HY-P76219	CD299 Protein, Human (HEK293, Fc)	Q9H2X3-1/NP_055072.3 (S78-E399)	≥95%

Related Diseases

Diseases

Alias

West Nile Virus

West Nile Virus, Susceptibility To	Wnv
Wnv, Susceptibility To	West Nile Viral Infection
Encephalitis, West Nile Fever	West Nile Fever

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Severe Acute Respiratory Syndrome

Sars	Sars-Cov Infection
Sars-1	Sar Deficiency
Sars - [Severe Acute Respiratory Syndrome]

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Marburg Hemorrhagic Fever

Marburg Virus Disease	Marburg Disease
Green Monkey Disease	Mhf
Vervet Monkey Disease	Mard - [Marburg Disease]
Mvd - [Marburg Virus Disease]	Marburg Haemorrhagic Fever
Mhf - [Marburg Haemorrhagic Fever]

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Von Willebrand Disease, Type 1

Von Willebrand Disease Type 1	VWD1
Von Willebrand'S Disease 1	Von Willebrand Disease Type I
Von Willebrand Disease, Type I	Vwd, Type 1
Vwd Type 1	Von Willebrand Disease 1
Von Willebrand Factor Deficiency Type 1	Von Willebrand Disease, Type 1, Susceptibility To

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

West Nile Fever

Dengue Hemorrhagic Fever

Severe Dengue	Dengue Haemorrhagic Fever
Dhf	Severe Dengue Haemorrhagic Fever
Severe Dengue Fever	Dengue Shock Syndrome

Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever	Junin Hemorrhagic Fever
Hemorrhagic Fever, Argentinian	Ahf - [Argentinian Haemorrhagic Fever]
Argentine Haemorrhagic Fever	Junin Haemorrhagic Fever

Dengue Shock Syndrome

Dss

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis	Encephalitis, Tick-Borne
Central European Encephalitis	Far Eastern Tbe
Russian Spring-Summer Encephalitis	Taiga Encephalitis
West-Siberian Encephalitis	Western European Tick-Borne Encephalitis
Tbe	Encephalitis Tick-Borne
Encephalitis, Central European	Encephalitis, Far Eastern Russian

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Coronavirus Infectious Disease

Factor Viii Deficiency

Autosomal Hemophilia A	Hemophilia A
Autosomal Factor Viii Deficiency	Classic Hemophilia A
Congenital Factor Viii Disorder	Subhemophilia
Factor 8 Deficiency, Congenital	Factor Viii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02797	CLEC4M Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLEC4M	RGD	RGD:1561466
Others	CLEC4M	NCBI

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