CCL26 - C-C motif chemokine ligand 26 Gene

Homo sapiens

Also known as IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha

Gene ID: 10344 | Gene type: protein coding

About CCL26

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:75,769,524-75,791,597 (from NCBI)

This gene has 2 transcripts (splice variants), 81 orthologues and 25 paralogues. Broad expression in ovary (RPKM 2.0), adrenal (RPKM 0.7) and 14 other tissues.

Summary

This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an Antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate Chemokine Receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]

CCL26 Products(3)

mRNA	Protein	Name
NM_001371936.1	NP_001358865.1	C-C motif chemokine 26 precursor
NM_001371938.1	NP_001358867.1	C-C motif chemokine 26 precursor
NM_006072.4	NP_006063.1	C-C motif chemokine 26 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR3 chemokine receptor binding	IDA IDA: Inferred from direct assay	11425309	GOA
enables CX3C chemokine receptor binding	IDA IDA: Inferred from direct assay	20974991	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	10373330	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	11425309	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell chemotaxis	IDA IDA: Inferred from direct assay	10373330	GOA
involved in chemokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	10373330	GOA
involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	10373330	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	19525930	GOA
involved in positive regulation of chemotaxis	IDA IDA: Inferred from direct assay	10373330	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19525930	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10373330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL26 Protein Structure

IL8

0
94 a.a.

Protein Preferred Names

Protein Names

C-C motif chemokine 26

CC chemokine IMAC

Recombinant CCL26 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7163	Eotaxin-3/CCL26 Protein, Human	Q9Y258 (T24-L94)	≥95%
HY-P75606	Eotaxin-3/CCL26 Protein, Human (sf9)	Q9Y258 (M1-L94)	≥95%

Related Diseases

Diseases

Alias

Esophagitis

Acute Esophagitis

Heart Tumor

Intracavitary Tumors	Myocardial Tumors
Primary Cardiac Tumors, Childhood	Heart Neoplasm
Intracavitary Tumors Of The Heart	Neoplasm Of Myocardium

Churg-Strauss Syndrome

Eosinophilic Granulomatosis With Polyangiitis	Allergic Granulomatous Angiitis
Churg-Strauss Vasculitis	Allergic Angiitis
Egpa	Granulomatous Allergic Angiitis
Allergic Granulomatosis Angiitis	Allergic Angiitis And Granulomatosis
Allergic Granulomatosis	Allergic Granulomatous And Angiitis
Css

Tuberous Sclerosis

Tuberous Sclerosis Syndrome	Bourneville'S Disease
Epiloia	Cerebral Sclerosis
Tuberose Sclerosis	Tuberous Sclerosis 1
Bourneville Disease	Bourneville Phakomatosis
Pringle'S Disease

Eosinophilic Gastritis

Eosinophilic Enteropathy

Angiomyolipoma

Angiomyolipoma Of Kidney

Congenital Heart Defects, Hamartomas Of Tongue, And Polysyndactyly

Ostravik-Lindemann-Solberg Syndrome	CHDTHP
Heart Defect-Tongue Hamartoma-Polysyndactyly Syndrome	Orstavik Lindemann Solberg Syndrome
Heart Defect - Tongue Hamartoma - Polysyndactyly Syndrome	Heart Defect, Tongue Hamartoma And Polysyndactyly
Hamartoma

Tuberous Sclerosis 1

Tuberous Sclerosis Complex	Tuberous Sclerosis
Bourneville Syndrome	TSC1
Tuberose Sclerosis	Ts
Tuberous Sclerosis-1	Bourneville Disease
Tsc	Bourneville Phakomatosis
Cerebral Sclerosis	Sclerosis Tuberosa
Tuberous Sclerosis, Type 1

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Hypereosinophilic Syndrome

Eosinophilia	HES
Eosinophilic Leukocytosis	Hypereosinophilic Syndrome, Idiopathic
Idiopathic Hypereosinophilic Syndrome	Disseminated Eosinophilic Collagen Disease
Eosinophilic Disorder	Disorders With Increased Eosinophil Counts

Eosinophilic Gastroenteritis

Eosinophilic Enteritis	Ege
Eosinophilic Gastroenterocolitis	Eosinophilic Esophagitis
Eosinophilic Gastritis	Eosinophilic Gastroenteropathy
Gastroenteritis, Eosinophilic	Eosinophilic Enteropathy

Esophageal Candidiasis

Candidiasis Of The Esophagus	Candida Esophagitis
Candidal Esophagitis	Esophageal Moniliasis
Esophageal Thrush

Dyskinesia Of Esophagus

Esophageal Motility Disorders	Dyskinesia Of Oesophagus
Esophageal Dysmotility	Esophageal Motility Disorder
Oesophageal Dysmotility	Oesophageal Motor Disorder
Esophageal Spasm

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Monkeypox

Monkeypox Virus Infections

Peptic Esophagitis

Reflux Esophagitis	Peptic Reflux Disease
Reflux Oesophagitis	Esophagitis, Peptic
Gastro-Esophageal Reflux Disease With Esophagitis

Gastroduodenitis

Abcd Syndrome

ABCDS	Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness
Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Endomyocardial Fibrosis

Becker'S Disease	Obscure African Cardiomyopathy
African Endomyocardial Fibrosis	Endomyocardial Sclerosis
EMF	Becker Muscular Dystrophy

Nasal Cavity Disease

Disorder Of Nasal Cavity

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

Respiratory Allergy

Airway Allergy

Common Cold

Acute Coryza	Acute Nasopharyngitis
Acute Rhinitis	Acute Viral Rhinopharyngitis
Nasopharyngitis - Acute	Nasopharyngitis, Acute
Rhino-Sinusitis	Rhinosinusitis
Common Colds	Acute Infective Rhinitis
Cold	Coryza
Head Cold	Infective Nasopharyngitis
Rhinopharyngitis	Acute Nasal Catarrh
Infective Rhinitis	Acute Nasopharyngeal Catarrh
Infective Nasopharyngitis Nos	Nasopharyngitis Nos
Epipharyngitis	Mucositis Nos
Inflammatory Disease Of Mucous Membrane	Mucosal Inflammation

Contact Dermatitis

Contact Dermatitis/Eczema	Contact Eczema
Dermatitis Venenata	Dermatitis, Venenata
Dermatitis Contact	Dermatitis, Contact

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02096	CCL26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCL26	MGD	MGI:3589281
Canis familiaris	CCL26	VGNC	VGNC:38888
Bos taurus	CCL26	VGNC	VGNC:106677
Felis catus	CCL26	VGNC	VGNC:107744
Macaca mulatta	CCL26	VGNC	VGNC:70701
Rattus norvegicus	CCL26	RGD	RGD:1587817
Others	CCL26	NCBI