BTN3A3 - butyrophilin subfamily 3 member A3 Gene

Homo sapiens

Also known as BTF3; BTN3.3

Gene ID: 10384 | Gene type: protein coding

About BTN3A3

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,440,504-26,453,415 (from NCBI)

This gene has 15 transcripts (splice variants), 41 orthologues and 15 paralogues. Ubiquitous expression in spleen (RPKM 36.1), lymph node (RPKM 22.4) and 24 other tissues.

Summary

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

BTN3A3 Products(3)

mRNA	Protein	Name
NM_001242803.2	NP_001229732.1	butyrophilin subfamily 3 member A3 isoform c
NM_006994.5	NP_008925.1	butyrophilin subfamily 3 member A3 isoform a precursor
NM_197974.3	NP_932078.2	butyrophilin subfamily 3 member A3 isoform b

BTN3A3 Protein Structure

V-set

PRY

SPRY

0
100
200
300
400
500
584 a.a.

Protein Preferred Names

Protein Names

butyrophilin subfamily 3 member A3

butyrophilin 3

Recombinant BTN3A3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7685	BTN3A3 Protein, Human (HEK293, His)	O00478 (Q30-W248)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01675	BTN3A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BTN3A3	NCBI

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