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1040

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (4) Bacterial (2) Calcium Channel (5) Drug Derivative (1) Drug Metabolite (5) Endothelin Receptor (2) FAK (1) Fluorescent Dye (2) GABA Receptor (1) HIV (1) Influenza Virus (1) Isotope-Labeled Compounds (3) MEK (2) Thrombin (1) Transmembrane Glycoprotein (2)
By Research Areas:	Cancer (10) Cardiovascular Disease (12) Endocrinology (2) Infection (3) Metabolic Disease (4) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1040

Cy5.5-COOH Cyanine 5.5 carboxylic acid	Fluorescent Dye	Others
CY5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH shows narrow absorption spectrum, and high sensitivity and stability .

HY-B1040

Ftaxilide	Bacterial	Infection
Ftaxilide is a novel antituberculosis agent.

HY-101918

*DS-1040* Tosylate**	Thrombin	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases .

HY-B0284

Nifedipine 15+ Cited Publications BAY-a-1040	Calcium Channel Autophagy	Cardiovascular Disease Cancer
Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-11103

Sitaxsentan sodium 1 Publications Verification IPI 1040 sodium; TBC11251 sodium	Endothelin Receptor	Cardiovascular Disease Endocrinology
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors.

HY-50295

CI-1040 Maximum Cited Publications 22 Publications Verification PD 184352	MEK Apoptosis	Cancer
CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC₅₀ of 17 nM for MEK1.

HY-N1040

13-Hydroxy-8,11,13-podocarpatriene-18-oic acid	Others	Others
13-Hydroxy-8,11,13-podocarpatriene-18-oic acid is a compound isolated from the bark of Pinus yunnanensis Franch .

HY-D1040A

CY5.5-COOH chloride Cyanine 5.5 carboxylic acid chloride	Fluorescent Dye	Others
CY5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH chloride shows narrow absorption spectrum, and high sensitivity and stability .

HY-169784

PPI-1040	Drug Derivative	Metabolic Disease
PPI-1040 is a synthetic PlsEtn, a precursor of plasmalogens. PPI-1040 is an orally available plasmalogen analog that increases plasmalogen in several peripheral tissues of Pex7 low allele mice. PPI-1040 has the potential to replace deficient plasmalogen and inhibit chondrodysplasia punctata (RCDP).

HY-76520

Sitaxsentan IPI 1040; TBC-11251	Endothelin Receptor	Cardiovascular Disease Endocrinology
Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist.

HY-B0284R

Nifedipine (Standard) BAY-a-1040 (Standard)	Calcium Channel Autophagy	Cardiovascular Disease Cancer
Nifedipine (Standard) is the analytical standard of Nifedipine. This product is intended for research and analytical applications. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-B0284S1

Nifedipine-d4 BAY-a-1040-d₄	Isotope-Labeled Compounds Calcium Channel Autophagy	Cardiovascular Disease Cancer
Nifedipine-d₄ is the deuterium labeled Nifedipine. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-P1822

*BDC2.5 mimotope 1040-31*	Transmembrane Glycoprotein	Metabolic Disease
BDC2.5 mimotope 1040-31, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg ⁺T cells .

HY-P1822A

*BDC2.5 mimotope 1040-31 TFA*	Transmembrane Glycoprotein	Metabolic Disease
BDC2.5 mimotope 1040-31 TFA, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg ⁺T cells .

HY-B0284S2

Nifedipine-13C8 BAY-a-1040-¹³C₈	Isotope-Labeled Compounds Calcium Channel Autophagy	Cardiovascular Disease
Nifedipine-13C8 is a deuterated labeled Nifedipine . Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-135356

m-Nifedipine	Drug Metabolite	Cardiovascular Disease
m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies .

HY-W019726

Dehydro Nifedipine BAY-b 4759	Drug Metabolite	Cardiovascular Disease Cancer
Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .

HY-139558

Zapnometinib PD0184264; ATR-002	MEK Influenza Virus Bacterial	Infection Cancer
Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC₅₀ of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities .

HY-135356R

m-Nifedipine (Standard)	Drug Metabolite	Cardiovascular Disease
m-Nifedipine (Standard) is the analytical standard of m-Nifedipine. This product is intended for research and analytical applications. m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies .

HY-W019726R

Dehydro Nifedipine (Standard)	Drug Metabolite	Cardiovascular Disease Cancer
Dehydro Nifedipine (Standard) is the analytical standard of Dehydro Nifedipine. This product is intended for research and analytical applications. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .

HY-W019726S1

Dehydro Nifedipine-13C,d3 BAY-b 4759-¹³C,d₃	Isotope-Labeled Compounds Drug Metabolite	Cancer
Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine . Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .

HY-122844

Ifebemtinib 1 Publications Verification BI-853520; IN-10018	FAK	Cancer
Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC₅₀=1?nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC₅₀s of 900?nM and 1040?nM, respectively .

HY-162074

Nipamovir	HIV	Infection
Nipamovir is a nitroimidazole prodrug. Nipamovir shows comparable antiviral activity to SAMT-247 (HY-102077) and NS-1040 in both cellular assays and a human ex vivo model of HIV infection, along with low toxicity. Nipamovir has EC₅₀ values of 3.64±3.28 and 3.23±2.81 μM for CEM-SS/HIV-1RF and hPBMC/HIV-192HT599, respectively .

HY-B0284S

Nifedipine-d6 1 Publications Verification BAY-a-1040-d₆	Calcium Channel	Cardiovascular Disease Cancer
Nifedipine-d₆ is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.

HY-101359

TPMPA	GABA Receptor	Neurological Disease
TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABA_C receptor (K_B = 2.1 μM), but not to interact with GABA_A (K_B = 320 μM) or GABA_B receptors (EC₅₀ = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells .

Cat. No.	Product Name	Type

HY-D1040

Cy5.5-COOH Cyanine 5.5 carboxylic acid	Fluorescent Dyes/Probes
CY5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH shows narrow absorption spectrum, and high sensitivity and stability .

HY-D1040A

CY5.5-COOH chloride Cyanine 5.5 carboxylic acid chloride	Fluorescent Dyes/Probes
CY5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH chloride shows narrow absorption spectrum, and high sensitivity and stability .

Cat. No.	Product Name	Target	Research Area

HY-P1822

*BDC2.5 mimotope 1040-31*	Transmembrane Glycoprotein	Metabolic Disease
BDC2.5 mimotope 1040-31, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg ⁺T cells .

HY-P1822A

*BDC2.5 mimotope 1040-31 TFA*	Transmembrane Glycoprotein	Metabolic Disease
BDC2.5 mimotope 1040-31 TFA, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg ⁺T cells .

HY-P1910

*BDC2.5 mimotope 1040-51*	Peptides	Metabolic Disease
BDC2.5 mimotope 1040-51 is a mimotope peptide for diabetogenic T cell clone BDC2.5. isolated from non-obese diabetic mice .

HY-P5488

*BDC2.5 Mimotope 1040-63*	Peptides	Others
BDC2.5 Mimotope 1040-63 is a biological active peptide. (The TCR transgenic model (BDC2.5) mimitope was used in type 1 diabetes (T1D) study. T1D is an autoimmune disease in which T cells mediate damage to pancreatic islet b cells. T1D is caused by autoreactive T cell destruction of insulin-producing cells. BDC2.5 mimotope was utilized to support the study on antigen presentation of antigenic peptides to islet autoantigen-specific T cells.)

Cat. No.	Product Name	Chemical Structure

HY-B0284S

Nifedipine-d6 1 Publications Verification
Nifedipine-d₆ is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.

HY-B0284S1

Nifedipine-d4
Nifedipine-d₄ is the deuterium labeled Nifedipine. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-B0284S2

Nifedipine-13C8
Nifedipine-13C8 is a deuterated labeled Nifedipine . Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-W019726S1

Dehydro Nifedipine-13C,d3
Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine . Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81305

	PP1C alpha Antibody (YA1040) Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit; Catalytic subunit; PP1A; PP1A_HUMAN; PP1alpha; PP2C ALPHA; PP2CA; Ppp1ca; Protein Phosphatase 2C Alpha Isoform; Serine threonine protein phosphatase PP1 alpha catalytic subunit; Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit.	WB, IHC-F, IHC-P, ICC/IF	Human
	PP1C alpha Antibody (YA1040) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1040), targeting PP1C alpha, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). PP1C alpha Antibody (YA1040) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

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