2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Nifedipine-d6

Nifedipine-d6  (Synonyms: BAY-a-1040-d6)

Cat. No.: HY-B0284S Purity: ≥98.0%
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Nifedipine-d6 is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.

For research use only. We do not sell to patients.

Nifedipine-d<sub>6</sub> Chemical Structure

Nifedipine-d6 Chemical Structure

CAS No. : 1188266-14-9

Size Price Stock Quantity
1 mg USD 220 In-stock
5 mg USD 770 In-stock
10 mg USD 1300 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Nifedipine-d6:

Nifedipine-d6 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nifedipine-d6

View All Calcium Channel Isoform Specific Products:

View All Isoforms
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nifedipine-d6 is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.

Molecular Weight

352.37

Formula

C17H12D6N2O6
CAS No.
Unlabeled CAS

21829-25-4
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(N1)=C(C(OC([2H])([2H])[2H])=O)C(C(C(OC([2H])([2H])[2H])=O)=C1C)C2=CC=CC=C2[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (283.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (283.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.28 mM; ultrasonic and warming and heat to 80°C)

H2O : 0.1 mg/mL (0.28 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8379 mL 14.1896 mL 28.3793 mL
5 mM 0.5676 mL 2.8379 mL 5.6759 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (3.55 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.8379 mL 14.1896 mL 28.3793 mL 70.9482 mL
5 mM 0.5676 mL 2.8379 mL 5.6759 mL 14.1896 mL
10 mM 0.2838 mL 1.4190 mL 2.8379 mL 7.0948 mL
15 mM 0.1892 mL 0.9460 mL 1.8920 mL 4.7299 mL
20 mM 0.1419 mL 0.7095 mL 1.4190 mL 3.5474 mL
25 mM 0.1135 mL 0.5676 mL 1.1352 mL 2.8379 mL
30 mM 0.0946 mL 0.4730 mL 0.9460 mL 2.3649 mL
40 mM 0.0709 mL 0.3547 mL 0.7095 mL 1.7737 mL
50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4190 mL
60 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1825 mL
80 mM 0.0355 mL 0.1774 mL 0.3547 mL 0.8869 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7095 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nifedipine-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nifedipine-d61188266-14-9BAY-a-1040-d6Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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