2. Gene
  3. WFDC2 - WAP four-disulfide core domain 2 Gene

WFDC2 - WAP four-disulfide core domain 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HE4; WAP5; EDDM4; dJ461P17.6

Gene ID: 10406 | Gene type: protein coding

About WFDC2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,469,753-45,481,532 (from NCBI)

This gene has 7 transcripts (splice variants) and 100 orthologues. Biased expression in salivary gland (RPKM 317.9), endometrium (RPKM 117.3) and 8 other tissues.

Summary

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

WFDC2 Products(1)

mRNA Protein Name
NM_006103.4 NP_006094.3 WAP four-disulfide core domain protein 2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25362534 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WFDC2 Protein Structure

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (32 - 73)

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (76 - 122)

  • 0
  • 100
  • 124 a.a.
Protein Preferred Names Protein Names

WAP four-disulfide core domain protein 2

WAP domain containing protein HE4-V4

WFDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
WFDC2 Q14508 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
WFDC2 Q14508 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
WFDC2 Q14508 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
WFDC2 Q14508 SLC22A23 Homo sapiens A1A5C7-2
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 SLC22A23 Homo sapiens A1A5C7-2
Y2H Array
32296183
Intra
WFDC2 Q14508 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
WFDC2 Q14508 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
WFDC2 Q14508 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
WFDC2 Q14508 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
WFDC2 Q14508 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
WFDC2 Q14508 ANXA2 Homo sapiens P07355
Anti Bait CoIP
25362534
Intra
WFDC2 Q14508 ANXA2 Homo sapiens P07355
Anti Bait CoIP
31210752
Intra
WFDC2 Q14508 ANXA2 Homo sapiens P07355
IF
25362534
Intra
WFDC2 Q14508 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
WFDC2 Q14508 GORAB Homo sapiens Q5T7V8
Validated Y2H
32296183
Intra
WFDC2 Q14508 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 FKBP7 Homo sapiens Q9Y680
Anti Tag CoIP
33961781
Intra
WFDC2 Q14508 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
WFDC2 Q14508 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
WFDC2 Q14508 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
WFDC2 Q14508 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
WFDC2 Q14508 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
WFDC2 Q14508 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
WFDC2 Q14508 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 PANX1 Homo sapiens Q96RD7
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 PANX1 Homo sapiens Q96RD7
Validated Y2H
32296183
Intra
WFDC2 Q14508 PANX1 Homo sapiens Q96RD7
Y2H Array
32296183
Intra
WFDC2 Q14508 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
Intra
WFDC2 Q14508 COQ9 Homo sapiens O75208
Y2H Array
32296183
Intra
WFDC2 Q14508 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
WFDC2 Q14508 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WFDC2 Proteins

Cat. No. Product Name Accession Purity
HY-P71432 HE4/WFDC2 Protein, Human (HEK293, His) Q14508 (E31-F124) ≥95%

WFDC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81043 HE4 Antibody (YA889) WB, ICC/IF, IHC-P, IP, FC Human, Mouse

Related Diseases

Diseases Alias
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Malignant Ovarian Cyst
Ovarian Cyst

Ovarian Cysts
Mucinous Ovarian Cystadenoma

Mucinous Cystadenoma Of Ovary

Ovarian Mucinous Cystadenoma
Ovarian Mucinous Cystadenocarcinoma

Mucinous Cystadenocarcinoma Of Ovary
Ovarian Cystadenoma

Cystoma Serosum Simplex

Simple Cystoma Of Ovary

Simple Cystoma Of The Ovary
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15811 WFDC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WFDC2 VGNC VGNC:54267
Rattus norvegicus WFDC2 RGD RGD:628757
Macaca mulatta WFDC2 VGNC VGNC:78993
Mus musculus WFDC2 MGD MGI:1914951
Bos taurus WFDC2 VGNC VGNC:36933
Others WFDC2 NCBI