2. Gene
  3. VAV3 - vav guanine nucleotide exchange factor 3 Gene

VAV3 - vav guanine nucleotide exchange factor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 10451 | Gene type: protein coding

About VAV3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:107,571,161-107,965,180 (from NCBI)

This gene has 15 transcripts (splice variants), 296 orthologues and 22 paralogues. Broad expression in kidney (RPKM 10.0), skin (RPKM 8.3) and 17 other tissues.

Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

VAV3 Products(2)

mRNA Protein Name
NM_001079874.2 NP_001073343.1 guanine nucleotide exchange factor VAV3 isoform 2
NM_006113.5 NP_006104.4 guanine nucleotide exchange factor VAV3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables guanyl-nucleotide exchange factor activity EXP
EXP: Inferred from Experiment
8990121 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12577067 GOA
Biological Process GO Annotation Evidence Reference Source
involved in B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17875758 GOA
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
17875758 GOA
involved in positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
17875758 GOA
involved in regulation of GTPase activity IGI
IGI: Inferred from genetic interaction
22467863 GOA
NOT involved in regulation of cell size IGI
IGI: Inferred from genetic interaction
22467863 GOA
involved in regulation of cell size IGI
IGI: Inferred from genetic interaction
22467863 GOA
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
17875758 GOA
Cellular Component GO Annotation Evidence Reference Source
located in immunological synapse IDA
IDA: Inferred from direct assay
15708849 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAV3 Protein Structure

CAMSAP_CH

CAMSAP_CH: CAMSAP CH domain (19 - 103)

RhoGEF

RhoGEF: RhoGEF domain (196 - 370)

PH

PH: PH domain (411 - 501)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (514 - 563)

SH3_2

SH3_2: Variant SH3 domain (597 - 658)

SH2

SH2: SH2 domain (672 - 746)

SH3_2

SH3_2: Variant SH3 domain (798 - 845)

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  • 847 a.a.
Protein Preferred Names Protein Names

guanine nucleotide exchange factor VAV3

VAV-3

VAV3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VAV3 Q9UKW4 MET Homo sapiens P08581
FPS
24728074
Intra
VAV3 Q9UKW4 GRB2 Homo sapiens P62993
Y2H
18654987
Intra
VAV3 Q9UKW4 GRB2 Homo sapiens P62993
Y2H Array
32296183
Intra
VAV3 Q9UKW4 GRB2 Homo sapiens P62993
Y2H Prey Pooling
32296183
Intra
VAV3 Q9UKW4 GRB2 Homo sapiens P62993
Y2H Pooling
20936779
Intra
VAV3 Q9UKW4 GAB1 Homo sapiens Q13480
FPS
24728074
Intra
VAV3 Q9UKW4 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
VAV3 Q9UKW4 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
VAV3 Q9UKW4 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra
VAV3 Q9UKW4 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra
VAV3 Q9UKW4 CBLB Homo sapiens Q13191
Y2H Prey Pooling
32296183
Intra
VAV3 Q9UKW4 CBLB Homo sapiens Q13191
Y2H Array
32296183
Intra
VAV3 Q9UKW4 PIK3R1 Homo sapiens P27986
Anti Bait CoIP
16982329
Cross: Cross-species interaction Intra: Intraspecies interaction

VAV3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82770 VAV3 Antibody (YA2515) WB, ICC/IF, IP, FC Human, Mouse

Related Diseases

Diseases Alias
Anterior Foramen Magnum Meningioma

Meningioma Of The Anterior Foramen Magnum
Osteopetrosis

Marble Bone Disease

Albers-Schonberg Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15614 VAV3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VAV3 MGD MGI:1888518
Bos taurus VAV3 VGNC VGNC:36774
Rattus norvegicus VAV3 RGD RGD:1565941
Canis familiaris VAV3 VGNC VGNC:48237
Macaca mulatta VAV3 VGNC VGNC:78759
Felis catus VAV3 VGNC VGNC:66927