GPNMB - glycoprotein nmb Gene

Homo sapiens

Also known as NMB; HGFIN; PLCA3

Gene ID: 10457 | Gene type: protein coding

About GPNMB

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,246,775-23,275,108 (from NCBI)

This gene has 15 transcripts (splice variants), 205 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in skin (RPKM 225.4), gall bladder (RPKM 143.5) and 17 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GPNMB Products(2)

mRNA	Protein	Name
NM_001005340.2	NP_001005340.1	transmembrane glycoprotein NMB isoform a precursor
NM_002510.3	NP_002501.1	transmembrane glycoprotein NMB isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparin binding	IDA IDA: Inferred from direct assay	19350579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12609765	GOA
enables receptor ligand activity	IMP IMP: Inferred from mutant phenotype	19350579	GOA
enables syndecan binding	IPI IPI: Inferred from physical interaction	19350579	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell signaling	IMP IMP: Inferred from mutant phenotype	19350579	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	19350579	GOA
involved in negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	19350579	GOA
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	19350579	GOA
involved in negative regulation of cytokine production	IDA IDA: Inferred from direct assay	19350579	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	20711474	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	19350579	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	22891158	GOA
involved in regulation of tissue remodeling	IDA IDA: Inferred from direct assay	25010402	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	19350579	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	12609765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPNMB Protein Structure

PKD

0
100
200
300
400
500
572 a.a.

Protein Preferred Names

Protein Names

transmembrane glycoprotein NMB

glycoprotein (transmembrane) nmb

Recombinant GPNMB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70836	GPNMB/Osteoactivin Protein, Human (HEK293, His)	Q14956-1 (A22-P486)	≥95%
HY-P75950	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His)	Q14956-2 (A22-P474)	≥95%
HY-P75951	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc)	Q14956-2 (A22-P474)	≥95%

Related Diseases

Diseases

Alias

Amyloidosis, Primary Localized Cutaneous, 3

Amyloidosis Cutis Dyschromica	PLCA3
Acd	Primary Localized Cutaneous Amyloidosis 3
Amyloidosis Cutis Dyschromia

Lichen Amyloidosis

Amyloid Lichen	Lichen Amyloidosus
Amyloidosis, Primary Cutaneous

Macular Amyloidosis

Amyloidosis, Macular

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Borderline Glaucoma

Preglaucoma

Ocular Pigment Dispersion With Or Without Glaucoma

Pigment Dispersion Syndrome	Glaucoma-Related Pigment Dispersion Syndrome
OPDG	Pds
Glaucoma, Pigment-Dispersion Type	Gpds1
Pigment-Dispersion Type Glaucoma	Pigment-Dispersion Syndrome
Glaucoma, Open-Angle

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis	Niemann-Pick Diseases
Lipoid Histiocytosis	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency Disease	Lipid Histiocytosis
Neuronal Cholesterol Lipidosis	Neuronal Lipidosis
Npd	Sphingomyelinase Deficiency
Niemann-Pick Disease, Type A

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Takayasu Arteritis

Aortic Arch Syndrome	Pulseless Disease
Takayasu'S Arteritis	Idiopathic Aortitis
Young Female Arteritis	Aortic Arch Arteritis
Aortic Arches Defect	Aortic Arch Defects
Takayasu Disease	Aortic Arch Syndromes
Takayasu'S Disease	Ta
Obliterative Aortitis	Aortic Arch Giant-Cell Arteritis
Subclavian-Carotid Obstruction Syndrome	Idiopathic Medial Aortopathy And Arteriopathy
Takayasu Syndrome	Obliterative Brachiocephalic Arteritis Syndrome
Raeder-Harbitz Syndrome	Chronic Subclavian-Carotid Obstruction Syndrome
Giant-Cell Aortitis	Takayasu Aortitis
Nonspecific Aortoarteritis	Sclerosing Aortitis And Arteritis
Martorell 2 Syndrome	Young Female Aortic Arch Arteritis Syndrome

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Lymphangioleiomyomatosis

Lymphangiomyomatosis	LAM
Lung Lymphangioleiomyomatosis	Pulmonary Lymphangioleiomyomatosis
Lymphangioleiomyomatosis, Somatic	Lymphangio-Myomatosis

Iris Disease

Iris Diseases

Gaucher Disease, Type I

Glucocerebrosidase Deficiency	Acid Beta-Glucosidase Deficiency
Gba Deficiency	GD1
Gd I	Gaucher Disease, Noncerebral Juvenile
Gaucher Disease Type 1	Gaucher Disease Type I
Gaucher'S Disease Type I	Gaucher Disease
Gd 1	Non-Cerebral Juvenile Gaucher Disease
GD	Gaucher Disease 1
Adult Non-Neuronopathic Gaucher Disease	Noncerebral Juvenile Gaucher Disease
Type 1 Gaucher Disease	Gaucher Disease, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-141604	Glembatumumab vedotin	Inhibitor	99.90%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99205	Glembatumumab		99.69%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05648	GPNMB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPNMB	MGD	MGI:1934765
Macaca mulatta	GPNMB	VGNC	VGNC:73123
Rattus norvegicus	GPNMB	RGD	RGD:71008
Felis catus	GPNMB	VGNC	VGNC:67413
Canis familiaris	GPNMB	VGNC	VGNC:41389
Bos taurus	GPNMB	VGNC	VGNC:29541
Others	GPNMB	NCBI

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