LRRC41 - leucine rich repeat containing 41 Gene

Homo sapiens

Also known as MUF1; PP7759

Gene ID: 10489 | Gene type: protein coding

About LRRC41

Cytogenetic location: 1p34.1-p33 Genomic coordinates (GRCh38): 1:46,277,462-46,303,616 (from NCBI)

This gene has 7 transcripts (splice variants) and 176 orthologues. Ubiquitous expression in thyroid (RPKM 20.0), ovary (RPKM 19.8) and 25 other tissues.

Summary

Predicted to enable identical protein binding activity. Predicted to be involved in protein ubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRC41 Products(1)

mRNA	Protein	Name
NM_006369.5	NP_006360.3	leucine-rich repeat-containing protein 41

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leucine-rich repeat-containing protein 41

MUF1 protein (MUF1)

LRRC41 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LRRC41	Q15345	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	LRRC41	Q15345	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	LRRC41	Q15345	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	LRRC41	Q15345	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	SMUG1	Homo sapiens	Q53HV7-2	Y2H Array	32296183
Intra	LRRC41	Q15345	SMUG1	Homo sapiens	Q53HV7-2	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	SMUG1	Homo sapiens	Q53HV7-2	Validated Y2H	32296183
Intra	LRRC41	Q15345	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	LRRC41	Q15345	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	FHL5	Homo sapiens	Q5TD97	Validated Y2H	32296183
Intra	LRRC41	Q15345	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	LRRC41	Q15345	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	LRRC41	Q15345	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	LRRC41	Q15345	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
Intra	LRRC41	Q15345	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183
Intra	LRRC41	Q15345	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Xia-Gibbs Syndrome

Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome	XIGIS
Mrd25	Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome
Mental Retardation, Autosomal Dominant 25, Formerly	Mrd25, Formerly
Autosomal Dominant Mental Retardation 25	Autosomal Dominant Intellectual Disability 25
Xgs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS07819	LRRC41 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LRRC41	VGNC	VGNC:63299
Mus musculus	LRRC41	MGD	MGI:2441984
Rattus norvegicus	LRRC41	RGD	RGD:1311221
Macaca mulatta	LRRC41	VGNC	VGNC:100000
Canis familiaris	LRRC41	VGNC	VGNC:42798

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