2. Gene
  3. FHL5 - four and a half LIM domains 5 Gene

FHL5 - four and a half LIM domains 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACT; FHL-5; dJ393D12.2; 1700027G07Rik

Gene ID: 9457 | Gene type: protein coding

About FHL5

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:96,562,574-96,618,626 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 16.0), fat (RPKM 12.3) and 18 other tissues.

Summary

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]

FHL5 Products(4)

mRNA Protein Name
NM_001170807.3 NP_001164278.1 four and a half LIM domains protein 5
NM_001322466.2 NP_001309395.1 four and a half LIM domains protein 5
NM_001322467.1 NP_001309396.1 four and a half LIM domains protein 5
NM_020482.6 NP_065228.4 four and a half LIM domains protein 5
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FHL5 Protein Structure

LIM

LIM: LIM domain (41 - 96)

LIM

LIM: LIM domain (102 - 159)

LIM

LIM: LIM domain (163 - 216)

LIM

LIM: LIM domain (222 - 276)

  • 0
  • 100
  • 200
  • 284 a.a.
Protein Preferred Names Protein Names

four and a half LIM domains protein 5

LIM protein ACT

FHL5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FHL5 Q5TD97 ZNF131 Homo sapiens P52739-2
Anti Tag CoIP
28514442
Intra
FHL5 Q5TD97 ZNF564 Homo sapiens Q8TBZ8
Validated Y2H
32296183
Intra
FHL5 Q5TD97 KIR2DL4 Homo sapiens Q99706
Validated Y2H
32296183
Intra
FHL5 Q5TD97 HDX Homo sapiens Q7Z353
Validated Y2H
32296183
Intra
FHL5 Q5TD97 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
FHL5 Q5TD97 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
FHL5 Q5TD97 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
FHL5 Q5TD97 IP6K3 Homo sapiens Q96PC2
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
FHL5 Q5TD97 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
FHL5 Q5TD97 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
FHL5 Q5TD97 SHFL Homo sapiens Q9NUL5-4
Validated Y2H
32296183
Intra
FHL5 Q5TD97 HAPLN2 Homo sapiens Q9GZV7
Validated Y2H
32296183
Intra
FHL5 Q5TD97 CDC20B Homo sapiens Q86Y33-5
Validated Y2H
32296183
Intra
FHL5 Q5TD97 DLGAP4 Homo sapiens Q9Y2H0-1
Validated Y2H
32296183
Intra
FHL5 Q5TD97 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra
FHL5 Q5TD97 SAXO4 Homo sapiens Q7Z5V6-2
Y2H Array
32296183
Intra
FHL5 Q5TD97 ZNF613 Homo sapiens Q6PF04
Validated Y2H
32296183
Intra
FHL5 Q5TD97 NUFIP2 Homo sapiens Q7Z417
Validated Y2H
32296183
Intra
FHL5 Q5TD97 BBC3 Homo sapiens Q96PG8
Validated Y2H
32296183
Intra
FHL5 Q5TD97 COL26A1 Homo sapiens Q96A83-2
Y2H Array
32814053
Intra
FHL5 Q5TD97 COL26A1 Homo sapiens Q96A83-2
Validated Y2H
32814053
Intra
FHL5 Q5TD97 COL26A1 Homo sapiens Q96A83-2
Y2H Pooling
32814053
Intra
FHL5 Q5TD97 MISP Homo sapiens Q8IVT2
Validated Y2H
32296183
Intra
FHL5 Q5TD97 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
32296183
Intra
FHL5 Q5TD97 TXN2 Homo sapiens Q99757
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ZNF408 Homo sapiens Q9H9D4
Validated Y2H
32296183
Cross
FHL5 Q5TD97 Hoxa1 Mus musculus P09022
Y2H
23088713
Cross
FHL5 Q5TD97 Hoxa1 Mus musculus P09022
Pull Down
23088713
Intra
FHL5 Q5TD97 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
32296183
Intra
FHL5 Q5TD97 PLEKHA2 Homo sapiens Q9HB19
Validated Y2H
32296183
Intra
FHL5 Q5TD97 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
FHL5 Q5TD97 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
FHL5 Q5TD97 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
FHL5 Q5TD97 MYOZ3 Homo sapiens Q8TDC0
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ZNF251 Homo sapiens Q9BRH9
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ZNF440 Homo sapiens Q8IYI8
Validated Y2H
32296183
Intra
FHL5 Q5TD97 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
FHL5 Q5TD97 CNNM3 Homo sapiens Q8NE01
Validated Y2H
32296183
Intra
FHL5 Q5TD97 DNAL4 Homo sapiens O96015
Y2H Pooling
16189514
Intra
FHL5 Q5TD97 DNAL4 Homo sapiens O96015
Y2H
21516116
Intra
FHL5 Q5TD97 RAB3IL1 Homo sapiens Q8TBN0
Validated Y2H
32296183
Intra
FHL5 Q5TD97 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ATOSB Homo sapiens Q7L5A3
Y2H
21516116
Intra
FHL5 Q5TD97 ATOSB Homo sapiens Q7L5A3
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ZNF764 Homo sapiens Q96H86
Validated Y2H
32296183
Intra
FHL5 Q5TD97 MAGOHB Homo sapiens Q96A72
Validated Y2H
32296183
Intra
FHL5 Q5TD97 SCNM1 Homo sapiens Q9BWG6
Anti Tag CoIP
33961781
Intra
FHL5 Q5TD97 SCNM1 Homo sapiens Q9BWG6
Anti Tag CoIP
28514442
Intra
FHL5 Q5TD97 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
FHL5 Q5TD97 NPDC1 Homo sapiens Q9NQX5
Validated Y2H
32296183
Intra
FHL5 Q5TD97 HEY2 Homo sapiens Q9UBP5
Validated Y2H
32296183
Intra
FHL5 Q5TD97 GARIN6 Homo sapiens Q8NEG0
Validated Y2H
32296183
Intra
FHL5 Q5TD97 CTSZ Homo sapiens Q9UBR2
Validated Y2H
32296183
Intra
FHL5 Q5TD97 ADAMTSL5 Homo sapiens Q6ZMM2
Validated Y2H
32296183
Intra
FHL5 Q5TD97 RAB26 Homo sapiens Q9ULW5
Validated Y2H
32296183
Intra
FHL5 Q5TD97 RAB26 Homo sapiens Q9ULW5
Y2H Prey Pooling
32296183
Intra
FHL5 Q5TD97 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Migraine Without Aura

Common Migraine

Migraine With Or Without Aura, Susceptibility To

Migraine Without Aura, Susceptibility To

Acute Migraine Without Aura
Migraine With Aura

Classic Migraine

Migraine With Typical Aura

Migraine Accompagnée

Complicated Migraine

Classical Migraine

Acute Migraine With Aura
Frontometaphyseal Dysplasia

Fmd

Dysplasia, Frontometaphyseal
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04937 FHL5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FHL5 VGNC VGNC:62267
Rattus norvegicus FHL5 RGD RGD:1307056
Canis familiaris FHL5 VGNC VGNC:40874
Mus musculus FHL5 MGD MGI:1913192
Bos taurus FHL5 VGNC VGNC:29002
Macaca mulatta FHL5 VGNC VGNC:72521
Others FHL5 NCBI