PRDX4 - peroxiredoxin 4 Gene

Homo sapiens

Also known as PRX-4; AOE372; AOE37-2; HEL-S-97n

Gene ID: 10549 | Gene type: protein coding

About PRDX4

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:23,667,493-23,686,397 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in pancreas (RPKM 49.0), liver (RPKM 22.7) and 25 other tissues.

Summary

The protein encoded by this gene is an antioxidant Enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

PRDX4 Products(1)

mRNA	Protein	Name
NM_006406.2	NP_006397.1	peroxiredoxin-4 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	21916849	GOA
enables molecular sequestering activity	IDA IDA: Inferred from direct assay	21916849	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17644091	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX4 Protein Structure

AhpC-TSA

1-cysPrx_C

0
100
200
271 a.a.

Protein Preferred Names

Protein Names

peroxiredoxin-4

antioxidant enzyme AOE372

PRDX4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRDX4	Q13162	TXNDC5	Homo sapiens	Q8NBS9	Enzymatic Study	21057456
Intra	PRDX4	Q13162	TBXA2R	Homo sapiens	P21731	Pull Down	17644091
Intra	PRDX4	Q13162	TBXA2R	Homo sapiens	P21731	Anti Tag CoIP	17644091
Intra	PRDX4	Q13162	TBXA2R	Homo sapiens	P21731	Y2H	17644091
Intra	PRDX4	Q13162	PRDX1	Homo sapiens	Q06830	Anti Tag CoIP	33961781
Intra	PRDX4	Q13162	LBP	Homo sapiens	P18428	Anti Tag CoIP	21988832
Intra	PRDX4	Q13162	LBP	Homo sapiens	P18428	Pull Down	21988832
Intra	PRDX4	Q13162	P4HB	Homo sapiens	P07237	Enzymatic Study	21057456

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71232	PRDX4 Protein, Human (His)	Q13162 (W38-N271)	≥95%

PRDX4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81698	Peroxiredoxin 4 Antibody (YA1443)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Filariasis

Disease Due To Superfamily Filarioidea	Bancroftian Filarial Fever
Mumu	Wanganga
Bancroftian Filariasis	Wuchereriosis
Brugiosis	Malayan Filariasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11077	PRDX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRDX4	VGNC	VGNC:64347
Macaca mulatta	PRDX4	VGNC	VGNC:76272
Bos taurus	PRDX4	VGNC	VGNC:33302
Rattus norvegicus	PRDX4	RGD	RGD:620043
Canis familiaris	PRDX4	VGNC	VGNC:44952
Mus musculus	PRDX4	MGD	MGI:1859815
Others	PRDX4	NCBI

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